A novel mononuclear platinum(II) complex, [PtLCl]Cl (1, where L = N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-(bis(2-ethylthioethyl)amino)acetamide), was synthesized containing an S,N,S-donor monochloroplatinum(II) moiety tethered to a planar 2-(4-aminophenyl)benzoxazole unit… Continue reading Enhanced anti-cancer efficacy to cancer cells by a novel monofunctional mononuclear platinum(II) complex containing a mixed S,N,S-donor ligand
Leah Pandiscia, PhD
May 22, 2018
As of February 2017, approximately 7639 amphibian species have been described in the AmphibiaWeb database. However, only 20 cathelicidin-like antimicrobial… Continue reading The first identified cathelicidin from tree frogs possesses anti-inflammatory and partial LPS neutralization activities
Leah Pandiscia, PhD
May 22, 2018
Herein, a pair of enantiomers, (S)-PPPtriAm and (R)-PPPtriAm, with three chiral substituents and their raceme rac-PPPtriAm derived from conjugated luminogen pentaphenylpyrrole… Continue reading Aggregation-induced emission enhancement and aggregation-induced circular dichroism of chiral pentaphenylpyrrole derivatives and their helical self-assembly
Leah Pandiscia, PhD
May 24, 2018
Leah Pandiscia, PhD
May 22, 2018
Site-specific conjugation is a leading trend in the development of protein conjugates, including antibody–drug conjugates (ADCs), suitable for targeted cancer… Continue reading High-Yield Site-Specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues
Leah Pandiscia, PhD
May 22, 2018
D-amino acid oxidases (DAAO) are stereospecific enzymes which are generally almost inactive towards L-enantiomer in neutral solution when L-, D-amino… Continue reading PH-Dependent Enantioselectivity of D-amino Acid Oxidase in Aqueous Solution
Leah Pandiscia, PhD
May 22, 2018
Both hydrogen-bonding and hydrophobic interactions play a significant role in molecular assembly, including self-assembly of proteins and peptides. In this… Continue reading Formation of Annular Protofibrillar Assembly by Cysteine Tripeptide: Unraveling the Interactions with NMR, FTIR, and Molecular Dynamics
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Highly water-soluble cationic palladium porphyrin as a sensitizer and 9,10-bis(4-trimethylammoniumphenyl)anthracene as an emitter were newly synthesized. They were shown to… Continue reading Efficient Upconversion by Highly Water-Soluble Cationic Sensitizer and Emitter in Aqueous Solutions with DNA
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
In flies, Centrosomin (Cnn) forms a phosphorylation-dependent scaffold that recruits proteins to the mitotic centrosome, but how Cnn assembles into… Continue reading Structural Basis for Mitotic Centrosome Assembly in Flies
Leah Pandiscia, PhD
July 28, 2017
The snake venoms are complex mixtures containing many bioactive peptides and proteins; some of them are aimed to protect the… Continue reading Zn(II) and Ni(II) complexes with poly-histidyl peptides derived from a snake venom
Leah Pandiscia, PhD
July 28, 2017
Amyloidosis is primarily characterized by the deposition of misfolded protein aggregates. Although the natural polyphenols have long been known as… Continue reading Gallic acid induced dose dependent inhibition of lysozyme fibrillation
Leah Pandiscia, PhD
July 28, 2017
Trp is the most spectroscopically informative aromatic amino acid of proteins. However, the near-UV circular dichroism (CD) spectrum of Trp… Continue reading Probing Tertiary Structure of Proteins Using Single Trp Mutations with Circular Dichroism at Low Temperature
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Physicochemical characterization of CeO2NPs using UV–vis, FTIR and XRD have confirmed the characteristic identity and fluorite phase of their crystalline… Continue reading Cerium oxide nanoparticles promote HSA fibrillation in vitro
Leah Pandiscia, PhD
July 28, 2017
The present investigation was focused on the removal of dissolved organics and suspended solids from tannery saline wastewater [TSWW]Raw, known… Continue reading Sequential oxic-anoxic bio reactor for the treatment of tannery saline wastewater using halophilic and filamentous bacteria
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Human ferritin (HFn) nanocaging is becoming an appealing platform for anticancer drugs delivery. However, protein aggregation always occurs during the… Continue reading High hydrostatic pressure encapsulation of doxorubicin in ferritin nanocages with enhanced efficiency
Leah Pandiscia, PhD
July 28, 2017