Miniproteins simplify the protein-folding problem, allowing the dissection of forces that stabilize protein structures. Here we describe PPa-Tyr, a designed… Continue reading Engineering protein stability with atomic precision in a monomeric miniprotein
Leah Pandiscia, PhD
July 28, 2017
Searching for specific G-quadruplex DNA probes is important for study of the function of G-rich gene sequence, as well as… Continue reading G-quadruplex DNA fluorescence sensing by a bis-amine-substituted styrylquinolinium dye
Leah Pandiscia, PhD
July 28, 2017
The traditionally used Central American medicinal plant Pluchea odorata, known as an anti-inflammatory and cancer cell growth-inhibiting remedy, was subjected to… Continue reading Isolation of eudesmanes from Pluchea odorata and evaluation of their effects on cancer cell growth and tumor invasiveness in vitro
Leah Pandiscia, PhD
July 28, 2017
Homologous Recombination enables faithful repair of the deleterious double strand breaks of DNA. This pathway relies on Rad51 to catalyze… Continue reading Functional effects of diphosphomimetic mutations at cAbl-mediated phosphorylation sites on Rad51 recombinase activity
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
A new nitrogen-containing phenolic glycoside, moringaside A (1), and a new megastigmane glycoside, moringamegastigmane A (2), were isolated from the… Continue reading Stimulators of acylated ghrelin secretion from Moringa oleifera leaves
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Four series of new hybrid molecules with 7-chloroquinoline and arylamidine moieties joined through the rigid -O- (groups I (2a-g) and II (5a-g)) or flexible… Continue reading New quinoline-arylamidine hybrids: Synthesis, DNA/RNA binding and antitumor activity
Leah Pandiscia, PhD
July 28, 2017
Intrinsically disordered proteins (IDPs) are involved in many pivotal cellular processes including phosphorylation and signalling. The structural and functional effects… Continue reading A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins – Lessons from the sodium proton exchanger 1 (NHE1)
Leah Pandiscia, PhD
July 28, 2017
It is usually believed that γ-ray interaction with biomolecules is intermediately performed by reactive oxygen species (ROS) produced from radiolysis… Continue reading Preferential role of iron in heme degradation of hemoglobin upon gamma irradiation
Leah Pandiscia, PhD
July 28, 2017
Anionic Peptides are molecules rich in aspartic acid (Asp) and/or glutamic acid (Glu) residues in the primary structure. This work presents, for the first time, structural… Continue reading Structure and in vitro activities of a Copper II-chelating anionic peptide from the venom of the scorpion Tityus stigmurus
Leah Pandiscia, PhD
July 28, 2017
A versatile reagent for the chiral resolution and determination of the absolute configuration of benzylic alcohols, (−)-3-menthoxybiphenyl-4-carboxylic acid, is reported.… Continue reading 3-Menthoxybiphenyl-4-carboxylic acid: a versatile resolving agent and reagent for determination of the absolute configuration of benzylic alcohols
Leah Pandiscia, PhD
July 28, 2017
Herein, we investigated the effect of the chitosan nanoparticles (CsNP) on the structure, dynamics, and activity of trypsin. The enzyme… Continue reading Chitosan Nanoparticles-Trypsin Interactions: Bio-physicochemical and Molecular Dynamics Simulation Studies
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
A pair of new tetranorlabdane diterpenoid epimers, named elettarins A (1) and B (2), together with five known labdane diterpenes… Continue reading New tetranorlabdane diterpenoids from the fruits of Elettaria cardamomum Maton
Leah Pandiscia, PhD
July 28, 2017
Apelin is a peptide ligand for a class A G-protein coupled receptor called the apelin receptor (AR or APJ) that… Continue reading Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands
Leah Pandiscia, PhD
July 28, 2017
Lectins play crucial roles for innate immune responses in invertebrates by recognizing and eliminating pathogens. In this study, a lectin… Continue reading Molecular and functional characterization of a glycosylated Galactose-Binding lectin from Mytilus californianus
Leah Pandiscia, PhD
July 28, 2017
TBC1D4 (also known as AS160) is a Rab·GTPase-activating protein (RabGAP) which functions in insulin signaling. TBC1D4 is critical for translocation… Continue reading The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017