To understand the role of ribose G-quartets and how they affect the properties of G-quadruplex structures, we studied three systems… Continue reading Unexpected Position-dependent Effects of Ribose G-quartets in G-quadruplexes
Leah Pandiscia, PhD
July 28, 2017
An investigation on the chemical constituents in the root barks of Litsea glutinosa was performed for the first time. Three new lignan… Continue reading New lignan glycosides from the root barks of Litsea glutinosa
Leah Pandiscia, PhD
July 28, 2017
We report the development of a quantum dot (QD)-peptide-fullerene (C60) electron transfer (ET)-based nanobioconjugate for the visualization of membrane potential… Continue reading Quantum Dot-Peptide-Fullerene Bioconjugates for Visualization of In Vitro and In Vivo Cellular Membrane Potential
Leah Pandiscia, PhD
July 28, 2017
Alternative scaffolds for biomolecular recognition are being developed to overcome some of the limitations associated with immunoglobulin domains. The repeat-in-toxin… Continue reading Catch and Release: Engineered Allosterically-Regulated β-roll Peptides Enable On/Off Biomolecular Recognition
Leah Pandiscia, PhD
July 28, 2017
Uranium is the heaviest natural element, mainly found in aqueous medium as the hexavalent uranyl ion (UO22+). Bones are the… Continue reading Reactivity of U-associated osteopontin with lactoferrin: a one-to-many complex
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
β/γ-Crystallins, the predominant structural proteins in vertebrate lens with lifelong stability to maintain lens transparency, share a high similarity in… Continue reading Effects of cataract-causing mutations W59C and W151C on βB2-crystallin structure, stability and folding
Leah Pandiscia, PhD
July 28, 2017
Amyloid fibrillation is a nucleation-dependent process known be involved in the development of more than 20 progressive and chronic diseases.… Continue reading Probing Amylin Fibrillation at an Early Stage via a Tetracysteine-Recognising Fluorophore
Leah Pandiscia, PhD
July 28, 2017
Aptamer-based biosensing, which uses short, single-stranded nucleic acid segments to bind to a target, can be advantageous over antibody-based diagnostics… Continue reading Enhancing the Sensing Specificity of a MoS2 Nanosheet-Based FRET Aptasensor Using a Surface Blocking Strategy
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Poly-γ-glutamic acid (PGA) was modified with phosphorylating agents such as sodium metaphosphate and potassium metaphosphate in the culture medium of Bacillus… Continue reading Feasible protein aggregation of phosphorylated poly-γ-glutamic acid derivative from Bacillus subtilis (natto)
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Plants have developed defensive specialized metabolites over the course of evolution. In the genus Hordeum, which includes the important cereal crop… Continue reading Evolutionary changes in defensive specialized metabolism in the genus Hordeum
Leah Pandiscia, PhD
July 28, 2017
Tau-mediated toxicity in Alzheimer’s disease is thought to operate through low-n oligomers, rather than filamentous aggregates. However, the nature of oligomers and pathways… Continue reading Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability
Leah Pandiscia, PhD
July 28, 2017
Seven new compounds including four lanostane triterpenoids, lucidenic acids Q-S (1–3) and methyl ganoderate P (4), and three triterpene-farnesyl hydroquinone… Continue reading Triterpenes and meroterpenes from Ganoderma lucidum with inhibitory activity against HMGs reductase, aldose reductase and α-glucosidase
Leah Pandiscia, PhD
July 28, 2017
Allergen-specific sublingual immunotherapy (SLIT) is well known as an effective and non-invasive route to induce allergy desensitization. The goal of… Continue reading Enhanced sublingual immunotherapy by TAT-fused recombinant allergen in a murine rhinitis model
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Calicheamicin, γ1I, is a remarkable DNA binding-cleaving, enediyne-containing, natural product that exhibits potent antitumor activity. In this study, we used… Continue reading Circular Dichroism Analysis of the Calicheamicin-DNA Interaction Revisited
Leah Pandiscia, PhD
July 28, 2017
This manuscript describes the result of a series of electrochemical, spectroscopic and thermodynamic studies into oligonucleotide hairpin structures equipped with… Continue reading A study of the interactions of Hg(II) with T-T mispair containing hairpin loops
Leah Pandiscia, PhD
July 28, 2017
Seeds of tropical legumes posses a repertoire of proteinase inhibitors (PI) and the current study highlights some structural/functional features of… Continue reading Caesalpinia bonduc serine proteinase inhibitor CbTI–2: Exploring the conformational features and antimalarial activity
Leah Pandiscia, PhD
July 28, 2017