Leah Pandiscia, PhD
July 28, 2017
The evaluation of the structural stability and bioactivity of monoclonal antibodies (mAb) is a crucial step in the development of… Continue reading Biophysical study of bevacizumab structure and bioactivity under thermal and pH-stresses
Leah Pandiscia, PhD
July 28, 2017
Ferulic acid is a major phenolic acid found in numerous plant species in conjugated form. It binds to enzymes and… Continue reading Spectroscopic and thermodynamic studies on ferulic acid – alpha-2-macroglobulin interaction
Leah Pandiscia, PhD
July 28, 2017
The evaluation of the antimycobacterial activity of extracts of medicinal plants used by Mayos against tuberculosis and respiratory problems, allowed… Continue reading New Isoflavonoids from the Extract of Rhynchosia precatoria (Humb. & Bonpl. ex Willd.) DC. and their antimycobacterial activity
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Inhibition of glycation is an important approach for alleviating diabetic complications. Alliin, the most abundant sulphur compound in garlic has… Continue reading Inhibitory effect of alliin from Allium sativum on the glycation of superoxide dismutase
Leah Pandiscia, PhD
July 28, 2017
RAPTA compounds, ([Ru(η6-arene)(PTA)Cl2], PTA = 1,3,5-triaza-7-phosphaadamantane), have been reported to overcome drug resistance in cisplatin resistant cells. However, the exact mechanism of… Continue reading Biochemical and biophysical characterization of ruthenation of BRCA1 RING protein by RAPTA complexes and its E3 ubiquitin ligase activity
Leah Pandiscia, PhD
July 28, 2017
The synthesis and characterization of a family of LnIIIcomplexes (Ln = Gd(1), Tb(2), Dy(3), Ho(4) and Er (5)) of formula… Continue reading Synthesis, characterization, computational study, and biological relevance of a family of isostructural, mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) complexes containing pyridoxine, an essential ingredient of vitamin B6 enzyme
Leah Pandiscia, PhD
July 28, 2017
Cisplatin (CDDP) can form interprotein cross-links, leading to the formation of platinated oligomers. A dimer, a trimer and higher oligomers… Continue reading A comparison study on RNase A oligomerization induced by cisplatin, carboplatin and oxaliplatin
Leah Pandiscia, PhD
July 28, 2017
1-Aminocyclopropane-1-carboxylic acid oxidase (ACCO) is a non heme iron(II) containing enzyme that catalyzes the final step of the ethylene biosynthesis… Continue reading Characterization of Cu(II)-reconstituted ACC Oxidase using experimental and theoretical approaches
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The molecular interactions between pancreatic lipase (PL) and five triterpenoid saponins compounds, including tea saponin, oleanolic acid, betulin, ginsenoside Ro,… Continue reading The effect of triterpenoid saponins on pancreatic lipase in vitro: Activity, conformation, kinetics, thermodynamics and morphology
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Human papillomavirus (HPV)-6 and HPV11 are the major etiological causes of condylomata acuminate. HPV neutralization by vaccine-elicited neutralizing antibodies can… Continue reading Bacterially expressed human papillomavirus type 6 and 11 bivalent vaccine: Characterization, antigenicity and immunogenicity
Leah Pandiscia, PhD
July 28, 2017
Within this manuscript design, synthesis of novel 2-imidazolinyl substituted benzo[b]thieno-2-carboxamides bearing either benzimidazole or benzothiazole subunit and biological activity are… Continue reading Novel amidino substituted benzimidazole and benzothiazole benzo[b]thieno-2-carboxamides exert strong antiproliferative and DNA binding properties
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The delivery performance of non-viral gene vectors is greatly related to their intracellular kinetics. Cationic helical polypeptides with potent membrane… Continue reading Manipulating the Membrane Penetration Mechanism of Helical Polypeptides via Aromatic Modification for Efficient Gene Delivery
Leah Pandiscia, PhD
July 28, 2017