CDC14 is an essential dual-specificity phosphatase that counteracts CDK1 activity during anaphase to promote mitotic exit in Saccharomyces cerevisiae. Surprisingly, human… Continue reading Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Three new spongian diterpenes, ceylonins G–I (1–3), were isolated from the marine sponge Spongia ceylonensis collected in Indonesia, together with… Continue reading Ceylonins G–I: spongian diterpenes from the marine sponge Spongia ceylonensis
Leah Pandiscia, PhD
July 28, 2017
We investigated the effects of punctual A-to-V and A-to-T mutations in the amyloid precursor protein APP, corresponding to position 2… Continue reading Pathogenic Aβ A2V versus protective Aβ A2T mutation: Early stage aggregation and membrane interaction
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Light quality is an important environmental factor affecting the biosynthesis of photosynthetic pigments whose production seems to be affected not… Continue reading Monochromatic green light induces an aberrant accumulation of geranylgeranyled chlorophylls in plants
Leah Pandiscia, PhD
July 28, 2017
Introducing cell-selectivity in antimicrobial peptides (AMPs) without compromising the antimicrobial and anti-endotoxin properties is a crucial step towards the development… Continue reading Selective phenylalanine to proline substitution for improved antimicrobial and anticancer activities of peptides designed on phenylalanine heptad repeat
Leah Pandiscia, PhD
July 28, 2017
The present work reveals the study of interaction of a promising chemotherapeutic drug ciprofloxacin (CFX) with a model transport protein… Continue reading Binding of ciprofloxacin to bovine serum albumin: Photophysical and thermodynamic aspects
Leah Pandiscia, PhD
July 28, 2017
Cytokine-like protein 1 (CYTL1) is a small widely expressed secreted protein lacking significant primary sequence homology to any other known… Continue reading Biochemical and biophysical characterization of cytokine-like protein 1 (CYTL1)
Leah Pandiscia, PhD
July 28, 2017
Interleukin-22 (IL-22) belongs to the family of IL-10 cytokines and is involved in a wide number of human diseases, including… Continue reading Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces
Leah Pandiscia, PhD
July 28, 2017
Two new flavanone glycosides, named scugalerosides A and B (1-2), were isolated from the whole plant of Scutellaria galericulata. Their chemical… Continue reading Two new flavanone glycosides from Scutellaria galericulata with anti-inflammatory activities
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
In the present work, the interaction between HSA with three potential anti-trypanosomal drugs – (E)-2-benzylidene-hydrazine-carbothioamide (UTS); (E)-2-(3,4-difluoro-benzylidene)-hydrazine-carbothioamide (DFTS) and (E)-2-(2,3,4-trifluoro-benzylidene)-hydrazine-carbothioamide… Continue reading Investigation of interaction between human plasmatic albumin and potential fluorinated anti-trypanosomal drugs
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Curli are extracellular proteinaceous functional amyloid aggregates produced by Escherichia coli, Salmonella spp., and other enteric bacteria. Curli mediate host… Continue reading The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism
Leah Pandiscia, PhD
July 28, 2017
Interactions of cytochrome c (cyt c) with cardiolipin (CL) are important for both electron transfer and apoptotic functions of this… Continue reading Conformational properties of cardiolipin-bound cytochrome c
Leah Pandiscia, PhD
July 28, 2017
Conditionally disordered proteins can alternate between highly ordered and less ordered configurations under physiological conditions. Whereas protein function is often… Continue reading Chaperone activation by unfolding
Leah Pandiscia, PhD
July 28, 2017
A heterologously expressed form of the human Parkinson diseaseassociated protein α-synuclein with a 10-residue N-terminal extension is shown to form… Continue reading A soluble α-synuclein construct forms a dynamic tetramer
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017