Iron, an essential nutrient with limited bioavailability, requires specialized cellular mechanisms for uptake. Although iron uptake into the cytoplasm in… Continue reading Induced fit on heme binding to the Pseudomonas aeruginosa cytoplasmic protein (PhuS) drives interaction with heme oxygenase (HemO)
Leah Pandiscia, PhD
July 28, 2017
Peroxisome proliferator activated receptor (PPAR) γ coactivator-1α (PGC-1α) is a potent transcriptional coactivator of oxidative metabolism and is induced in… Continue reading Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex
Leah Pandiscia, PhD
July 28, 2017
Perception and response to nutritional iron availability by bacteria are essential to control cellular iron homeostasis. The Irr protein from Bradyrhizobium… Continue reading Control of bacterial iron homeostasis by manganese
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Hypochlorite, an oxidant generated in vivo by the innate immune system, kills invading pathogens largely by inducing the misfolding of… Continue reading Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin
Leah Pandiscia, PhD
July 28, 2017
Resorcylic acid lactones and dihydroxyphenylacetic acid lactones represent important pharmacophores with heat shock response and immune system modulatory activities. The… Continue reading Rational reprogramming of fungal polyketide first-ring cyclization
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Basic leucine zipper (bZip) transcription factors regulate cellular gene expression in response to a variety of extracellular signals and nutrient… Continue reading Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The studies presented here explore the relationship between protein packing and molecular flexibility using ligand-binding cavity mutants of T4 lysozyme.… Continue reading Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants
Leah Pandiscia, PhD
July 28, 2017
The histone fold forms the fundamental endoskeleton of the protein core of the nucleosome and is also found in several… Continue reading Experimental evidence for the role of domain swapping in the evolution of the histone fold
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
To provide high-resolution X-ray crystallographic structures of a peptide with the Trp-cage fold, we prepared a cyclized version of this… Continue reading Crystal and NMR structures of a Trp-cage mini-protein benchmark for computational fold prediction
Leah Pandiscia, PhD
July 28, 2017
Aβ42 oligomers play key roles in the pathogenesis of Alzheimer disease, but their structures remain elusive partly due to their… Continue reading Antiparallel Triple-strand Architecture for Prefibrillar Aβ42 Oligomers
Leah Pandiscia, PhD
July 28, 2017
DNA glycosylases are important editing enzymes that protect genomic stability by excising chemically modified nucleobases that alter normal DNA metabolism.… Continue reading Structure of a DNA glycosylase that unhooks interstrand cross-links
Leah Pandiscia, PhD
July 28, 2017
Cytochrome c (cyt c), required for electron transport in mitochondria, possesses a covalently attached heme cofactor. Attachment is catalyzed by… Continue reading Engineered holocytochrome c synthases that biosynthesize new cytochromes c
Leah Pandiscia, PhD
July 28, 2017
The covalent modification of therapeutic biomolecules has been broadly explored, leading to a number of clinically approved modified protein drugs.… Continue reading Supramolecular PEGylation of biopharmaceuticals
Leah Pandiscia, PhD
July 28, 2017
Parkinson’s disease is a highly debilitating neurodegenerative condition whose pathological hallmark is the presence in nerve cells of proteinacious deposits,… Continue reading Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation
Leah Pandiscia, PhD
July 28, 2017
Despite the ubiquity of helical membrane proteins in nature and their pharmacological importance, the mechanisms guiding their folding remain unclear.… Continue reading Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops
Leah Pandiscia, PhD
July 28, 2017