Leah Pandiscia, PhD
July 28, 2017
Amyloid light chain (AL) amyloidosis is a protein misfolding disease where immunoglobulin light chains sample partially folded states that lead… Continue reading Differential Effects on Light Chain Amyloid Formation Depend on Mutations and Type of Glycosaminoglycans
Leah Pandiscia, PhD
July 28, 2017
Aromatase (CYP19A1), the enzyme that converts androgens to estrogens, is of significant mechanistic and therapeutic interest. Crystal structures and computational… Continue reading Evidence for an Elevated Aspartate pKa in the Active Site of Human Aromatase
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Low density lipoprotein receptor (LDLR) was shown to mediate clearance of blood coagulation factor VIII (FVIII) from the circulation. To… Continue reading Mapping the Binding Region on the Low Density Lipoprotein Receptor for Blood Coagulation Factor VIII
Leah Pandiscia, PhD
July 28, 2017
Misfolding and aggregation of huntingtin is one of the hallmarks of Huntington disease, but the overall structure of these aggregates… Continue reading Structural Features and Domain Organization of Huntingtin Fibrils
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Chlamydia is an intracellular bacterium that establishes residence within parasitophorous compartments (inclusions) inside host cells. Chlamydial inclusions are uncoupled from the… Continue reading An α-Helical Core Encodes the Dual Functions of the Chlamydial Protein IncA
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
IRF4 is a unique member of the interferon regulatory factor (IRF) family playing critical regulatory roles in immune cell development,… Continue reading Structural Studies of IRF4 Reveal a Flexible Autoinhibitory Region and a Compact Linker Domain
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The activation of pyruvate formate-lyase (PFL) by pyruvate formate-lyase activating enzyme (PFL-AE) involves formation of a specific glycyl radical on… Continue reading Pyruvate Formate-lyase and Its Activation by Pyruvate Formate-lyase Activating Enzyme
Leah Pandiscia, PhD
July 28, 2017
We previously identified Treponema pallidum repeat proteins TprC/D, TprF, and TprI as candidate outer membrane proteins (OMPs) and subsequently demonstrated that TprC is… Continue reading Bipartite Topology of Treponema pallidumRepeat Proteins C/D and I
Leah Pandiscia, PhD
July 28, 2017
EsxA (ESAT-6), an important virulence factor of Mycobacterium tuberculosis, plays an essential role in phagosome rupture and bacterial cytosolic translocation within… Continue reading Characterization of Mycobacterium tuberculosis EsxA Membrane Insertion
Leah Pandiscia, PhD
July 28, 2017
Although trace levels of phosphorylated α-synuclein (α-syn) are detectable in normal brains, nearly all α-syn accumulated within Lewy bodies in… Continue reading Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization
Leah Pandiscia, PhD
July 28, 2017
Identification of factors contributing to the development of chronic obstructive pulmonary disease (COPD) is crucial for developing new treatments. An… Continue reading Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase
Leah Pandiscia, PhD
July 28, 2017
Cellular membrane disruption induced by β-amyloid (Aβ) peptides has been considered one of the major pathological mechanisms for Alzheimer disease.… Continue reading Distinct Membrane Disruption Pathways Are Induced by 40-Residue β-Amyloid Peptides
Leah Pandiscia, PhD
July 28, 2017
Protein modification by small ubiquitin-related modifiers (SUMOs) is essential and conserved in the malaria parasite, Plasmodium falciparum. We have previously shown… Continue reading haracterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems
Leah Pandiscia, PhD
July 28, 2017
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that trimethylates elongation factor-thermo-unstable (EF-Tu) on lysine 5. Lysine 5 methylation occurs in a… Continue reading Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase
Leah Pandiscia, PhD
July 28, 2017