Bla g 2 is a major indoor cockroach allergen associated with the development of asthma. Antigenic determinants on Bla g… Continue reading Antigenic Determinants of the Bilobal Cockroach Allergen Bla g 2
Leah Pandiscia, PhD
July 28, 2017
Some members of the class A β-lactamase family are capable of conferring resistance to the last resort antibiotics, carbapenems. A… Continue reading Role of the Conserved Disulfide Bridge in Class A Carbapenemases
Leah Pandiscia, PhD
July 28, 2017
All-trans-retinoic acid may be an important molecular signal in the postnatal control of eye size. The goal of this study… Continue reading Identification of Apolipoprotein A-I as a Retinoic Acid-binding Protein in the Eye
Leah Pandiscia, PhD
July 28, 2017
Development of a Plasmodium falciparum (Pf) transmission blocking vaccine (TBV) has the potential to significantly impact malaria control. Antibodies elicited against sexual… Continue reading Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of the Plasmodium falciparum Sexual Stage Protein Pfs230
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The cobalamin or B12 cofactor supports sulfur and one-carbon metabolism and the catabolism of odd-chain fatty acids, branched-chain amino acids and… Continue reading Coordination Chemistry Controls the Thiol Oxidase Activity of the B12 Trafficking Protein CblC
Leah Pandiscia, PhD
July 28, 2017
Protein-tyrosine phosphatase receptor type G (RPTPγ/PTPRG) interacts in vitro with contactin-3–6 (CNTN3–6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the… Continue reading Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues
Leah Pandiscia, PhD
July 28, 2017
The sirtuin family of proteins catalyze the NAD+-dependent deacylation of acyl-lysine residues. Humans encode seven sirtuins (Sirt1–7), and recent studies… Continue reading Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation
Leah Pandiscia, PhD
July 28, 2017
Bacterial ATP-binding cassette (ABC) transporters of transition metals are essential for acquisition of necessary elements from the environment. A large… Continue reading AztD, a Periplasmic Zinc Metallochaperone to an ATP-binding Cassette (ABC) Transporter System in Paracoccus denitrificans
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Multiple neurodegenerative diseases are caused by the aggregation of the human α-Synuclein (α-Syn) protein. α-Syn possesses high structural plasticity and… Continue reading Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles
Leah Pandiscia, PhD
July 28, 2017
Small interfering RNAs (siRNAs) are powerful tools to control gene expression. However, due to their poor cellular permeability and stability,… Continue reading A retro-inverso cell-penetrating peptide for siRNA delivery
Leah Pandiscia, PhD
July 28, 2017
Inositol 1,3,4,5,6-pentakisphosphate 2-kinases (IP5 2-Ks) comprise a family of enzymes in charge of synthesizing inositol hexakisphosphate (IP6) in eukaryotic cells. This… Continue reading The Crystal Structure of Mammalian Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Reveals a New Zinc Binding Site and Key Features for Protein Function
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Mammalian cytochrome c (Cytc) plays a key role in cellular life and death decisions, functioning as an electron carrier in the electron… Continue reading Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017