Cupredoxins are widespread copper-binding proteins, mainly involved in electron transfer pathways. They display a typical rigid greek key motif consisting… Continue reading Spectroscopic Characterization of a Green Copper Site in a Single-Domain Cupredoxin
Leah Pandiscia, PhD
July 28, 2017
Virus capsid assembly constitutes an attractive target for the development of antiviral therapies; a few experimental inhibitors of this process… Continue reading Rationally Designed Interfacial Peptides Are Efficient In VitroInhibitors of HIV-1 Capsid Assembly with Antiviral Activity
Leah Pandiscia, PhD
July 28, 2017
Bacterial growth in multicellular communities, or biofilms, offers many potential advantages over single-cell growth, including resistance to antimicrobial factors. Here… Continue reading Uropathogenic Escherichia coli Modulates Immune Responses and Its Curli Fimbriae Interact with the Antimicrobial Peptide LL-37
Leah Pandiscia, PhD
July 28, 2017
Four structurally unprecedented aconitane-type C19-diterpenoid alkaloid glycosides with isomeric arabinosyls, named aconicarmichosides A–D (1–4), were isolated from an aqueous extract… Continue reading Unprecedented C19-diterpenoid alkaloid glycosides from an aqueous extract of “fu zi”: Neoline 14-O-l-arabinosides with four isomeric l-anabinosyls
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R,8S-threo-dihydroxydehydrodiconiferyl… Continue reading Neolignan and monoterpene glycoside from the seeds of Pharbitis nil
Leah Pandiscia, PhD
July 28, 2017
The purpose of this study was to produce lysozyme-pullulan conjugates under mild Maillard reaction conditions and investigate the influence of… Continue reading Synthesis and structural characterization of lysozyme–pullulan conjugates obtained by the Maillard reaction
Leah Pandiscia, PhD
July 28, 2017
Pyroglutamate-modified amyloid-β (pEAβ) has been described as a relevant Aβ species in Alzheimer’s-disease-affected brains, with pEAβ (3–42) as a dominant isoform. Aβ (1–40) and… Continue reading Pyroglutamate-Modified Amyloid-β(3–42) Shows α-Helical Intermediates before Amyloid Formation
Leah Pandiscia, PhD
July 28, 2017
Two new compounds namely 7,4′-dihydroxy-2′-methoxy-3′-(3-methylbut-2-enyl)isoflavanone (1) and 5,7,3′-trihydroxy-8-(3-methylbut-2-enyl)-[6′′,6′′-dimethylpyrano(2′′,3′′:4′,5′)]isoflavone (4) were isolated from the root bark of Erythrina droogmansiana together with eight known… Continue reading Chemical constituents of the root bark of Erythrina droogmansiana
Leah Pandiscia, PhD
July 28, 2017
The strong and usually denaturing interaction between anionic surfactants (AS) and proteins/enzymes has both benefits and drawbacks: for example, it… Continue reading Refolding of SDS-Unfolded Proteins by Nonionic Surfactants
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Type 1 diabetes and thyroid disease are T cell-dependent autoimmune endocrinopathies. The standard substitutive administration of the deficient hormones does… Continue reading Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes
Leah Pandiscia, PhD
July 28, 2017
BPF (Bisphenol-F), a member of the bisphenol family, having a wide range of industrial applications is gradually replacing Bisphenol-A. It… Continue reading Binding of Bisphenol-F, a bisphenol analogue, to calf thymus DNA by multi-spectroscopic and molecular docking studies
Leah Pandiscia, PhD
July 28, 2017
In this report, L-diphenylalanine-decorated tetraphenylporphyrin (TPPtFFC) was synthesized and self-assembled into regular nano-architechtures. The morphology of the assemblies varied with… Continue reading J-aggregation in porphyrin nanoparticles induced by diphenylalanine
Leah Pandiscia, PhD
July 28, 2017
Infection, survival, and proliferation of pathogenic bacteria in humans depend on their capacity to impair host responses and acquire nutrients… Continue reading Unique Structure and Stability of HmuY, a Novel Heme-Binding Protein of Porphyromonas gingivalis
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor tyrosine kinases. EGFR is activated… Continue reading Modulating the Structure of EGFR with UV Light: New Possibilities in Cancer Therapy
Leah Pandiscia, PhD
July 28, 2017
Proteins constituting the presynaptic machinery of vesicle release undergo substantial conformational changes during the process of exocytosis. While changes in… Continue reading CHL1 Is a Selective Organizer of the Presynaptic Machinery Chaperoning the SNARE Complex
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017