Apolipoprotein E (apoE) is a major protein of the lipoprotein transport system that plays important roles in lipid homeostasis and… Continue reading Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia
Leah Pandiscia, PhD
July 28, 2017
The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is… Continue reading Novel African Trypanocidal Agents: Membrane Rigidifying Peptides
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
A transcriptome analysis identified Vibrio vulnificus cabABC genes which were preferentially expressed in biofilms. The cabABC genes were transcribed as a single operon. The cabA gene… Continue reading The cabABC Operon Essential for Biofilm and Rugose Colony Development in Vibrio vulnificus
Leah Pandiscia, PhD
July 28, 2017
A unique peptide toxin, named double-knot toxin (DkTx), was recently purified from the venom of the tarantula Ornithoctonus huwena and was found… Continue reading High Yield Production and Refolding of the Double-Knot Toxin, an Activator of TRPV1 Channels
Leah Pandiscia, PhD
July 28, 2017
Endoribonuclease E (RNase E) affects the composition and balance of the RNA population in Escherichia coli via degradation and processing of RNAs.… Continue reading Modulation of RNase E Activity by Alternative RNA Binding Sites
Leah Pandiscia, PhD
July 28, 2017
Prion diseases are transmissible spongiform encephalopathies in humans and animals, including scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle,… Continue reading Seeded Fibrillation as Molecular Basis of the Species Barrier in Human Prion Diseases
Leah Pandiscia, PhD
July 28, 2017
The computational protein design protocol Rosetta has been applied successfully to a wide variety of protein engineering problems. Here the… Continue reading Octarellin VI: Using Rosetta to Design a Putative Artificial (β/α)8 Protein
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
In some bacterial species and photosynthetic cohorts, including algae, the enzyme l,l-diaminopimelate aminotransferase (DapL) (E.C. 2.6.1.83) is involved in the anabolism… Continue reading L,L-Diaminopimelate Aminotransferase from Chlamydomonas reinhardtii: A Target for Algaecide Development
Leah Pandiscia, PhD
July 28, 2017
Leucine-rich repeat kinase 1 and 2 (LRRK1 and LRRK2) are large multidomain proteins containing kinase, GTPase and multiple protein-protein interaction… Continue reading Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
[FeFe]-hydrogenases reversibly catalyse molecular hydrogen evolution by reduction of two protons. Proton supply to the catalytic site (H-cluster) is essential… Continue reading Site Saturation Mutagenesis Demonstrates a Central Role for Cysteine 298 as Proton Donor to the Catalytic Site in CaHydA [FeFe]-Hydrogenase
Leah Pandiscia, PhD
July 28, 2017
Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as… Continue reading Machupo Virus Glycoprotein Determinants for Human Transferrin Receptor 1 Binding and Cell Entry
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Strepsirrhines are members of a primate suborder that has a distinctive set of features associated with the development of the… Continue reading Structural Analysis of a Repetitive Protein Sequence Motif in Strepsirrhine Primate Amelogenin
Leah Pandiscia, PhD
July 28, 2017
Autoinducer-2 (AI-2) mediated quorum sensing has been associated with the expression of virulence factors in a number of pathogenic organisms… Continue reading Identification of a Key Amino Acid of LuxS Involved in AI-2 Production in Campylobacter jejuni
Leah Pandiscia, PhD
July 28, 2017