Staphylococcus epidermidis is a leading nosocomial pathogen. In contrast to its more aggressive relative S. aureus, it causes chronic rather than acute… Continue reading Staphylococcus epidermidis Strategies to Avoid Killing by Human Neutrophils
Leah Pandiscia, PhD
July 28, 2017
Roseobacter denitrificans is a member of the widespread marine Roseobacter genus. We report the first characterization of a truncated hemoglobin from R. denitrificans (Rd. trHb)… Continue reading Peroxidase Activity and Involvement in the Oxidative Stress Response of Roseobacter denitrificans Truncated Hemoglobin
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Peptide-based packaging systems show great potential as safer drug delivery systems. They overcome problems associated with lipid-based or viral delivery… Continue reading Peptide Nanovesicles Formed by the Self-Assembly of Branched Amphiphilic Peptides
Leah Pandiscia, PhD
July 28, 2017
Fibers composed of type I collagen triple helices form the organic scaffold of bone and many other tissues, yet the… Continue reading Procollagen Triple Helix Assembly: An Unconventional Chaperone-Assisted Folding Paradigm
Leah Pandiscia, PhD
July 28, 2017
Enteroaggregative Escherichia coli (EAEC) is a leading cause of acute and persistent diarrhea worldwide. A recently emerged Shiga-toxin-producing strain of EAEC resulted… Continue reading Structural Insight into Host Recognition by Aggregative Adherence Fimbriae of Enteroaggregative Escherichia coli
Leah Pandiscia, PhD
July 28, 2017
Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer’s disease (AD).… Continue reading Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide
Leah Pandiscia, PhD
July 28, 2017
The osmolyte dimethylsulfoniopropionate (DMSP) is a key nutrient in marine environments and its catabolism by bacteria through enzymes known as… Continue reading Biochemical, Kinetic, and Spectroscopic Characterization of Ruegeria pomeroyi DddW—A Mononuclear Iron-Dependent DMSP Lyase
Leah Pandiscia, PhD
July 28, 2017
Oligomerization and aggregation of α-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson’s disease [1]. However,… Continue reading Dopamine-Induced Conformational Changes in Alpha-Synuclein
Leah Pandiscia, PhD
July 28, 2017
Many bacterial surface exposed proteins mediate the host-pathogen interaction more effectively in the presence of Ca2+. Leptospiral immunoglobulin-like (Lig) proteins,… Continue reading Big Domains Are Novel Ca2+-Binding Modules: Evidences from Big Domains of Leptospira Immunoglobulin-Like (Lig) Proteins
Leah Pandiscia, PhD
July 28, 2017
A novel neutrophil chemoattractant derived from collagen, proline-glycine-proline (PGP), has been recently characterized in chronic obstructive pulmonary disease (COPD). This… Continue reading Targeting Prolyl Endopeptidase with Valproic Acid as a Potential Modulator of Neutrophilic Inflammation
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Most enolases are homodimers. There are a few that are octamers, with the eight subunits arranged as a tetramer of… Continue reading Dissociation of the Octameric Enolase from S. Pyogenes – One Interface Stabilizes Another
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The fungus Aspergillus fumigatus is a leading infectious killer in immunocompromised patients. Calcineurin, a calmodulin (CaM)-dependent protein phosphatase comprised of calcineurin A… Continue reading Phosphorylation of Calcineurin at a Novel Serine-Proline Rich Region Orchestrates Hyphal Growth and Virulence in Aspergillus fumigatus
Leah Pandiscia, PhD
July 28, 2017
The botulinum neurotoxin serotype A light chain (BoNT/A LC) protease is the catalytic component responsible for the neuroparalysis that is… Continue reading Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A
Leah Pandiscia, PhD
July 28, 2017