Leah Pandiscia, PhD
July 28, 2017
The translationally-controlled tumor protein (TCTP) is a highly conserved, ubiquitously expressed, abundant protein that is broadly distributed among eukaryotes. Its biological function spans… Continue reading Ligand Binding Reveals a Role for Heme in Translationally-Controlled Tumor Protein Dimerization
Leah Pandiscia, PhD
July 28, 2017
Subunit vaccines are significantly more expensive to produce than traditional vaccines because they are based primarily on recombinant proteins that… Continue reading Algae-Produced Pfs25 Elicits Antibodies That Inhibit Malaria Transmission
Leah Pandiscia, PhD
July 28, 2017
This study examines the surface activity and resistance to phospholipase degradation of a fully-synthetic lung surfactant containing a novel diether… Continue reading Dynamic Surface Activity of a Fully Synthetic Phospholipase-Resistant Lipid/Peptide Lung Surfactant
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Bdellovibrio bacteriovorus is a δ-proteobacterium that preys upon Salmonella spp., E. coli, and other Gram-negative bacteria. Bdellovibrio can grow axenically (host-independent, HI, rare and mutation-driven)… Continue reading The Lifestyle Switch Protein Bd0108 of Bdellovibrio bacteriovorus Is an Intrinsically Disordered Protein
Leah Pandiscia, PhD
July 28, 2017
Many Gram-positive bacteria produce pore-forming exotoxins that contain a highly conserved, 12-residue domain (ECTGLAWEWWRT) that binds cholesterol. This domain is… Continue reading Oxpholipin 11D: An Anti-Inflammatory Peptide That Binds Cholesterol and Oxidized Phospholipids
Leah Pandiscia, PhD
July 28, 2017
We previously identified several peptide sequences that mimicked the terminal sugars of complex glycans. Using plant lectins as analogs of… Continue reading A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Synthetic mosquito oviposition attractants are sorely needed for surveillance and control programs for Culex species, which are major vectors of pathogens causing… Continue reading Reverse and Conventional Chemical Ecology Approaches for the Development of Oviposition Attractants for CulexMosquitoes
Leah Pandiscia, PhD
July 28, 2017
Legionella pneumophila is a pathogenic bacterium that can cause Legionnaires’ disease and other non-pneumonic infections in humans. This bacterium produces a… Continue reading Phenylalanine Hydroxylase from Legionella pneumophila Is a Thermostable Enzyme with a Major Functional Role in Pyomelanin Synthesis
Leah Pandiscia, PhD
July 28, 2017
Recent studies introduced two experimental protocols for converting full-length recombinant prion protein (rPrP) purified from E.coli into the infectious prion state (PrPSc)… Continue reading Contrasting Effects of Two Lipid Cofactors of Prion Replication on the Conformation of the Prion Protein
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Chlamydia trachomatis replicates in a parasitophorous membrane-bound compartment called an inclusion. The inclusions corrupt host vesicle trafficking networks to avoid the degradative… Continue reading Two Coiled-Coil Domains of Chlamydia trachomatis IncA Affect Membrane Fusion Events during Infection
Leah Pandiscia, PhD
July 28, 2017
Two yeast manganese superoxide dismutases (MnSOD), one from Saccharomyces cerevisiae mitochondria (ScMnSOD) and the other from Candida albicans cytosol (CaMnSODc), have most biochemical and… Continue reading Tetramerization Reinforces the Dimer Interface of MnSOD
Leah Pandiscia, PhD
July 28, 2017
Enrichment of four tandem repeats of guanine (G) rich and cytosine (C) rich sequences in functionally important regions of human… Continue reading Intramolecular Folding in Human ILPR Fragment with Three C-Rich Repeats
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Amino acid replacements at dozens of positions in the dimeric protein human, Cu,Zn superoxide dismutase (SOD1) can cause amyotrophic lateral… Continue reading Metal-Free ALS Variants of Dimeric Human Cu,Zn-Superoxide Dismutase Have Enhanced Populations of Monomeric Species
Leah Pandiscia, PhD
July 28, 2017
Uncomplicated infections of the urinary tract, caused by uropathogenic Escherichia coli, are among the most common diseases requiring medical intervention. A… Continue reading Mucosal Immunization with Iron Receptor Antigens Protects against Urinary Tract Infection
Leah Pandiscia, PhD
July 28, 2017