Griffithsin, a 121-residue protein isolated from a red algal Griffithsia sp., binds high mannose N-linked glycans of virus surface glycoproteins with… Continue reading Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin
Leah Pandiscia, PhD
July 28, 2017
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues. Infectious… Continue reading Leptospira interrogans Endostatin-Like Outer Membrane Proteins Bind Host Fibronectin, Laminin and Regulators of Complement
Leah Pandiscia, PhD
July 28, 2017
Despite the wide use of Caenorhabditis elegans as a model organism, the first virus naturally infecting this organism was not discovered until… Continue reading Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells
Leah Pandiscia, PhD
July 28, 2017
Guanine (G)-rich DNA readily forms four-stranded quadruplexes in vitro, but evidence for their participation in genome regulation is limited. We have… Continue reading A Parallel G Quadruplex-Binding Protein Regulates the Boundaries of DNA Elimination Events of Tetrahymena thermophila
Leah Pandiscia, PhD
July 28, 2017
The extrinsic apoptotic pathway is initiated by binding of a Fas ligand to the ectodomain of the surface death receptor… Continue reading Identification of the Calmodulin-Binding Domains of Fas Death Receptor
Leah Pandiscia, PhD
July 28, 2017
Tyrosinase (TYR) catalyzes the rate-limiting, first step in melanin production and its gene (TYR) is mutated in many cases of… Continue reading Albinism-Causing Mutations in Recombinant Human Tyrosinase Alter Intrinsic Enzymatic Activity
Leah Pandiscia, PhD
July 28, 2017
We have engineered pH sensitive binding proteins for the Fc portion of human immunoglobulin G (hIgG) (hFc) using two different… Continue reading Design of pH Sensitive Binding Proteins from the Hyperthermophilic Sso7d Scaffold
Leah Pandiscia, PhD
July 28, 2017
The type VI secretion system (T6SS) has emerged as an important mediator of interbacterial interactions. A T6SS from Pseudomonas aeruginosa targets at… Continue reading Structural Basis for Type VI Secretion Effector Recognition by a Cognate Immunity Protein
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
New insecticides are urgently needed because resistance to current insecticides allows resurgence of disease-transmitting mosquitoes while concerns for human toxicity… Continue reading Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
At the interface between T cell and antigen-presenting cell (APC), peptide antigen presented by MHC (pMHC) binds to the T… Continue reading Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity
Leah Pandiscia, PhD
July 28, 2017
Many neurodegenerative diseases are characterized by the conformational change of normal self-proteins into amyloidogenic, pathological conformers, which share structural properties… Continue reading Immunomodulation Targeting Abnormal Protein Conformation Reduces Pathology in a Mouse Model of Alzheimer’s Disease
Leah Pandiscia, PhD
July 28, 2017
Natural transformation, or competence, is an ability inherent to bacteria for the uptake of extracellular DNA. This process is central… Continue reading Pheromone Recognition and Selectivity by ComR Proteins among Streptococcus Species
Leah Pandiscia, PhD
July 28, 2017
MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression. Their precursors have a globally A-form helical geometry, which prevents most… Continue reading Helical Defects in MicroRNA Influence Protein Binding by TAR RNA Binding Protein
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Ceriporiopsis subvermispora oxalate oxidase (CsOxOx) is the first bicupin enzyme identified that catalyzes manganese-dependent oxidation of oxalate. In previous work, we… Continue reading Kinetic and Spectroscopic Studies of Bicupin Oxalate Oxidase and Putative Active Site Mutants
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Neuropilin (Nrp) receptors function as essential cell surface receptors for the Vascular Endothelial Growth Factor (VEGF) family of proangiogenic cytokines… Continue reading Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition
Leah Pandiscia, PhD
July 28, 2017