In nature, Escherichia coli are exposed to harsh and non-ideal growth environments—nutrients may be limiting, and cells are often challenged by oxidative… Continue reading Oxidative Stress Inactivates Cobalamin-Independent Methionine Synthase (MetE) in Escherichia coli
Leah Pandiscia, PhD
July 28, 2017
Artificial enzymes hold the potential to catalyze valuable reactions not observed in nature. One approach to build artificial enzymes introduces… Continue reading Thermostable Artificial Enzyme Isolated by In Vitro Selection
Leah Pandiscia, PhD
July 28, 2017
Pathogen reduction is a viable approach to ensure the continued safety of the blood supply against emerging pathogens. However, the… Continue reading Pathogen Reduction in Human Plasma Using an Ultrashort Pulsed Laser
Leah Pandiscia, PhD
July 28, 2017
Cytoplasmic dynein and dynactin participate in retrograde transport of organelles, checkpoint signaling and cell division. The principal subunits that mediate… Continue reading Dynein and Dynactin Leverage Their Bivalent Character to Form a High-Affinity Interaction
Leah Pandiscia, PhD
July 28, 2017
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a chromosomal architectural transcription factor involved in cell transformation and… Continue reading The Dimerization State of the Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2)
Leah Pandiscia, PhD
July 28, 2017
Staphylococcus aureus is an opportunistic pathogen that colonizes the skin and mucosal surfaces of mammals. Persistent staphylococcal infections often involve surface-associated… Continue reading Functional Amyloids Composed of Phenol Soluble Modulins Stabilize Staphylococcus aureus Biofilms
Leah Pandiscia, PhD
July 28, 2017
TRIM proteins play important roles in the innate immune defense against retroviral infection, including human immunodeficiency virus type-1 (HIV-1). Rhesus… Continue reading Rhesus TRIM5α Disrupts the HIV-1 Capsid at the InterHexamer Interfaces
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Aquaporin 0 (AQP0) formerly known as membrane intrinsic protein (MIP), is expressed exclusively in the lens during terminal differentiation of… Continue reading Thermal Stress Induced Aggregation of Aquaporin 0 (AQP0) and Protection by α-Crystallin via Its Chaperone Function
Leah Pandiscia, PhD
July 28, 2017
The deposition and oligomerization of amyloid β (Aβ) peptide plays a key role in the pathogenesis of Alzheimer’s disease (AD).… Continue reading The Influence of Spin-Labeled Fluorene Compounds on the Assembly and Toxicity of the Aβ Peptide
Leah Pandiscia, PhD
July 28, 2017
Facultative bacterial pathogens must adapt to multiple stimuli to persist in the environment or establish infection within a host. Temperature… Continue reading A Protein Thermometer Controls Temperature-Dependent Transcription of Flagellar Motility Genes in Listeria monocytogenes
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Serine proteinase inhibitors of the serpin family are well known as negative regulators of hemostasis, thrombolysis and innate immune responses.… Continue reading Biochemical Characterization of Anopheles gambiae SRPN6, a Malaria Parasite Invasion Marker in Mosquitoes
Leah Pandiscia, PhD
July 28, 2017
Cellulase enzymes deconstruct cellulose to glucose, and are often comprised of glycosylated linkers connecting glycoside hydrolases (GHs) to carbohydrate-binding modules… Continue reading Cellulase Linkers Are Optimized Based on Domain Type and Function: Insights from Sequence Analysis, Biophysical Measurements, and Molecular Simulation
Leah Pandiscia, PhD
July 28, 2017
AB toxins such as ricin and cholera toxin (CT) consist of an enzymatic A domain and a receptor-binding B domain.… Continue reading Modulation of Toxin Stability by 4-Phenylbutyric Acid and Negatively Charged Phospholipids
Leah Pandiscia, PhD
July 28, 2017
As a small stress response protein, human αB crystallin, detects protein destabilization that can alter structure and function to cause… Continue reading Hemoglobin Interactions with αB Crystallin: A Direct Test of Sensitivity to Protein Instability
Leah Pandiscia, PhD
July 28, 2017