Leah Pandiscia, PhD
July 28, 2017
The multidrug transporter AcrB in Escherichia coli exists and functions as a homo-trimer. The assembly process of obligate membrane protein oligomers, including… Continue reading AcrB Trimer Stability and Efflux Activity, Insight from Mutagenesis Studies
Leah Pandiscia, PhD
July 28, 2017
The glycoside hydrolases (GH) of Caldicellulosiruptor bescii are thermophilic enzymes, and therefore they can hydrolyze plant cell wall polysaccharides at high temperatures.… Continue reading Supplementing with Non-Glycoside Hydrolase Proteins Enhances Enzymatic Deconstruction of Plant Biomass
Leah Pandiscia, PhD
July 28, 2017
Two-component signal transduction systems, composed of histidine kinases (HK) and response regulators (RR), allow bacteria to respond to diverse environmental… Continue reading Genetic and Biochemical Dissection of a HisKA Domain Identifies Residues Required Exclusively for Kinase and Phosphatase Activities
Leah Pandiscia, PhD
July 28, 2017
Halogenation of organic compounds plays diverse roles in biochemistry, including selective chemical modification of proteins and improved oral absorption/blood-brain barrier… Continue reading Halogenation Generates Effective Modulators of Amyloid-Beta Aggregation and Neurotoxicity
Leah Pandiscia, PhD
July 28, 2017
Every lipid membrane fission event involves the association of two apposing bilayers, mediated by proteins that can promote membrane curvature,… Continue reading The Cytosolic Domain of Fis1 Binds and Reversibly Clusters Lipid Vesicles
Leah Pandiscia, PhD
July 28, 2017
The navel orangeworm, Amyelois transitella Walker (Lepidoptera: Pyralidae), is the most serious insect pest of almonds and pistachios in California for which… Continue reading Olfactory Proteins Mediating Chemical Communication in the Navel Orangeworm Moth, Amyelois transitella
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
To replicate in mammalian hosts, bacterial pathogens must acquire iron. The majority of iron is coordinated to the protoporphyrin ring… Continue reading Differential Function of Lip Residues in the Mechanism and Biology of an Anthrax Hemophore
Leah Pandiscia, PhD
July 28, 2017
The T3SS injectisome is a syringe-shaped macromolecular assembly found in pathogenic Gram-negative bacteria that allows for the direct delivery of… Continue reading A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Mutations in the human LMNA gene cause muscular dystrophy by mechanisms that are incompletely understood. The LMNA gene encodes A-type lamins, intermediate filaments that… Continue reading Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway
Leah Pandiscia, PhD
July 28, 2017
Mycobacterium tuberculosis (Mtb) employs multiple strategies to evade host immune responses and persist within macrophages. We have previously shown that the cell… Continue reading Mycobacterium tuberculosis Hip1 Modulates Macrophage Responses through Proteolysis of GroEL2
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Recently nanoparticle-based vaginal drug delivery formulations have been acquiring great attention for the administration of peptide based-vaccines or microbicides to… Continue reading Freeze-dried cylinders carrying chitosan nanoparticles for vaginal peptide delivery
Leah Pandiscia, PhD
July 28, 2017
Burn injuries are one of the most common types of trauma worldwide, and their unique physiology requires the development of… Continue reading Heparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injury
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Three polypyridines functionalized with pinene groups, (−)-‘dipineno’-[4,5:4″,5″]-fused 2,2′:6′,2″-terpyridine ((−)-1), (−)-1,3-di-(2-(4,5-pinene)pyridyl)benzene ((−)-2) and (−)-4,5-pinene-6′-phenyl-2,2′-bipyridine ((−)-3) were synthesized, and their structures were… Continue reading Configuration analysis of three chiral polypyridines functionalized with pinene groups
Leah Pandiscia, PhD
July 28, 2017
In the presented study, N-{[(5S)-3-(2-fluoro-4′-{[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl}biphenyl-4-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide (radezolid) was synthesized and characterized using FT-IR, Raman, ECD and NMR. The aim of this work… Continue reading Application of spectroscopic methods (FT-IR, Raman, ECD and NMR) in studies of identification and optical purity of radezolid
Leah Pandiscia, PhD
July 28, 2017
The low solubility of wheat gluten limits its accessibility. This work aimed to study the impact of ultrasonic pretreatments on… Continue reading Transglutaminase-set colloidal properties of wheat gluten with ultrasound pretreatments
Leah Pandiscia, PhD
July 28, 2017