The synthesis, characterization, and evaluation of a novel polymer–protein conjugate are reported here. The covalent conjugation of high-molecular weight poly(acrylic… Continue reading Protein Polymer Conjugates: Improving the Stability of Hemoglobin with Poly(acrylic acid)
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
A method is described to identify small molecule ligands that stabilize proteins. The procedure is based on the hypothesis that… Continue reading Stabilization of proteins by low molecular weight multi-ions
Leah Pandiscia, PhD
July 28, 2017
Hemocyanin has been shown to have potential antiviral activity against herpes simplex virus type-1. However, current liquid formulations have short… Continue reading Formulation of abalone hemocyanin with high antiviral activity and stability
Leah Pandiscia, PhD
July 28, 2017
Camelids and sharks possess a unique subclass of antibodies comprised of only heavy chains. The antigen binding fragments of these… Continue reading Isolation of a Highly Thermal Stable Lama Single Domain Antibody Specific for Staphylococcus aureusEnterotoxin B
Leah Pandiscia, PhD
July 28, 2017
Thermal stress was used to assess the stability of recombinant human erythropoietin (EPO) derived from Chinese hamster ovary cells. In… Continue reading Kinetic and Thermodynamic Analysis of Thermal Unfolding of Recombinant Erythropoietin
Leah Pandiscia, PhD
July 28, 2017
Thermally induced aggregates of α-chymotrypsinogen A and bovine granulocyte-colony stimulating factor in acidic solutions were characterized by a combination of static… Continue reading Nonnative Protein Polymers: Structure, Morphology, and Relation to Nucleation and Growth ☆
Leah Pandiscia, PhD
July 28, 2017
Candida parapsilosis ATCC 7330, a rich source of highly stereospecific oxidoreductases, catalyzes oxidation-reduction of a plethora of compounds yielding industrially… Continue reading A carbonyl reductase from Candida parapsilosis ATCC 7330: Substrate selectivity and enantiospecificity
Leah Pandiscia, PhD
July 28, 2017
Two types of Cu(II)–UMP-L coordination polymers, {[Cu2(UMP)2(bpda)2(H2O)3]·10H2O}n (1) and {[Cu2(UMP)2(bpe)2(H2O)2]·7H2O}n (2) (UMP = uridine 5′-monophosphate, bpda = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene, bpe = 1,2-bis(4-pyridyl)ethylene), were… Continue reading Unusual crystal structure and chirality of uridine 5′-monophosphate coordination polymer
Leah Pandiscia, PhD
July 28, 2017
Production of hyperthermostable enzymes in mesophilic hosts frequently causes undesired aggregation of these proteins. During production of Pyrococcus furiosus endo-… Continue reading Chaotropic heat treatment resolves native-like aggregation of a heterologously produced hyperthermostable laminarinase
Leah Pandiscia, PhD
July 28, 2017
The stabilization of a G-quadruplex structure in human telomeric DNA has become a promising strategy in the development of cancer… Continue reading Restriction of telomerase capping by short non-toxic peptides via arresting telomeric G-quadruplex
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The Ebola virus Viral Protein 24 (VP24) inhibits interferon signaling through its interaction with the human protein Karyopherin, thus impairing… Continue reading Computer aided design and NMR characterization of an oligopeptide targeting Ebola virus VP24 protein
Leah Pandiscia, PhD
July 28, 2017
The DNA interstrand cross-links of the antitumor drug ({[cis-Pt(NH3)2Cl]2(4,4´-methylenedianiline)}2+ (1) play a prevalent role in its antitumor effects. Complex 1 forms in DNA… Continue reading Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Two mononuclear copper (II) terpyridine complexes namely, [Cu(Btptpy) (ClO4)](ClO4) 1, and [Cu(Bttpy) (ClO4)](ClO4) 2, (Btptpy (L1) = 4’-(Benzothiophene)-2,2’:6′,2″-terpyridine, Bttpy (L2) = 4’-(Benzylthiazolyl)-2,2’:6′,2″-terpyridine) have been synthesized and characterized. Single crystal X-ray… Continue reading Novel mononuclear Cu (II) terpyridine complexes: Impact of fused ring thiophene and thiazole head groups towards DNA/BSA interaction, cleavage and antiproliferative activity on HepG2 and triple negative CAL-51 cell line
Leah Pandiscia, PhD
July 28, 2017
Calreticulin of Brugia malayi (BmCRT) play very important role in host-parasite interaction. In previous study it was found that BmCRT is responsible… Continue reading Monitoring thermal and chemical unfolding of Brugia malayi calreticulin using fluorescence and Circular Dichroism spectroscopy
Leah Pandiscia, PhD
July 28, 2017
Herein, we report the oncolytic activity of cationic, one-dimensional (1D) fibril assemblies formed from coil-sheet poly(L-lysine)-block-poly(L-threonine) (PLL-b-PLT) block copolypeptides for… Continue reading One-dimensional Poly(L-Lysine)-block-Poly(L-Threonine) Assemblies Exhibit Potent Anticancer Activity by Enhancing Membranolysis
Leah Pandiscia, PhD
July 28, 2017
The effect of oscillation induced by a frequency-dependent alternating current (AC) electric field to dissociate preformed amyloid fibrils has been… Continue reading Fibrillar disruption by AC electric field induced oscillation: A case study with human serum albumin
Leah Pandiscia, PhD
July 28, 2017
A series of 9-mer and 13-mer amide-bridged cyclic peptides derived from the linear prototype Ac-PKIIQSVGIS-Nle-K-Nle-NH2 (Toro et al. ChemBioChem2013) has been designed… Continue reading First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity#
Leah Pandiscia, PhD
July 28, 2017