The work introduces Tb(III)-centered luminescence of amino-modified silica nanoparticles doped with Tb(III) complexes for cellular imaging. For these purposes water-in-oil… Continue reading Cellular imaging by green luminescence of Tb(III)-doped aminomodified silica nanoparticles
Leah Pandiscia, PhD
July 28, 2017
Many degenerative disorder such as Parkinsons, Alzheimers, Huntingtons disease, etc are caused due to the deposition of amyloid fibrils, formed… Continue reading Trehalose and Magnesium Chloride Exert a Common Anti-amyloidogenic Effect Towards Hen Egg White Lysozyme
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson’s disease (PD). It is one… Continue reading S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation
Leah Pandiscia, PhD
July 28, 2017
This study presents a few bis(histidine) ligands working to build a small peptidic model system of zinc structural sites. Ferrocene-peptide… Continue reading Metal Coordination of Ferrocene-Histidine Conjugates
Leah Pandiscia, PhD
July 28, 2017
Protein interactions with surfactants are dependent on their physiochemical properties. The effect of cationic gemini surfactant hexanediyl-α,ω-bis-(N-(2-hydroxyethyl)-N-methylhexadecylammonium dibromide) on the… Continue reading Comparative effect of cationic gemini surfactant and its monomeric counterpart on the conformational stability and activity of lysozyme
Leah Pandiscia, PhD
July 28, 2017
Chiral sensing using fluorescent responses as output signals is an attractive technique for enantiodifferentiation in terms of its rapidity, high… Continue reading A cellulose-based chiral fluorescent sensor for aromatic nitro compounds with central, axial and planar chirality
Leah Pandiscia, PhD
July 28, 2017
Peptide-drug discovery using host-defense peptides becomes promising against antibiotic-resistant pathogens and cancer cells. Here, we customized the therapeutic activity of… Continue reading Mechanistic and structural basis of bioengineered bovine Cathelicidin-5 with optimized therapeutic activity
Leah Pandiscia, PhD
July 28, 2017
A novel surface-enhanced Raman scattering (SERS) response emerging from aptamers, complementary DNA (cDNA), p-aminothiophenol (PATP), and Au nanorods (GNRs) for detection… Continue reading Fabricating a Novel Raman Spectroscopy-Based Aptasensor for Rapidly Sensing Salmonella typhimurium
Leah Pandiscia, PhD
July 28, 2017
Calpains are calcium-activated proteases that have biomedical and biotechnological potential. Their activity is tightly regulated by their endogenous inhibitor, calpastatin… Continue reading Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin
Leah Pandiscia, PhD
July 28, 2017
HAMLET (Human Alpha-Lactalbumin Made LEthal to Tumor cells), a complex of oleic acid (OA) with partially unfolded human α-lactalbumin, shows… Continue reading Augmenting the cytotoxicity of oleic acid-protein complexes: Potential of target-specific antibodies
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
β -barrel membrane proteins (βMPs) form barrel-shaped pores in the outer membrane of Gram-negative bacteria, mitochondria, and chloroplasts. Because of the… Continue reading Engineering a Novel Porin OmpGF via Strand Replacement From Computational Analysis of Sequence Motif
Leah Pandiscia, PhD
July 28, 2017
Most of the important genomic regions, especially the G,C rich gene promoters, consist of sequences with potential to form G,C-tetraplexes… Continue reading Magnesium and Molecular crowding of the cosolutes stabilize the i-motif structure at physiological pH
Leah Pandiscia, PhD
July 28, 2017
An unusually thermostable G-quadruplex is formed by a sequence fragment of a naturally occurring ribozyme, the human CPEB3 ribozyme. Strong… Continue reading The 5′-AG₅CC-3′ fragment from the human CPEB3 ribozyme forms an ultrastable parallel RNA G-quadruplex
Leah Pandiscia, PhD
July 28, 2017
The interaction of IFN-β with its receptor IFNAR1 is vital for host-protective anti-viral and anti-proliferative responses, but signaling via this… Continue reading A hot-spot on interferon alpha/beta receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling
Leah Pandiscia, PhD
July 28, 2017
Disease associated genetic variations often cause intracellular enzyme inactivation, dysregulation and instability. However, allosteric communication of mutational effects to distant… Continue reading Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Surfactin is a Bacillus-produced natural lipopeptide, which can overcome the epithelial cell barriers for orally delivering insulin, but its ability to… Continue reading Surfactin variants for intra-intestinal delivery of insulin
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017