Cyclophilin catalyzes the ubiquitous process “peptidyl-prolyl cis-trans isomerization,” which plays a key role in protein folding, regulation, and function. Here, we present… Continue reading Unfolding of CPR3 Gets Initiated at the Active Site and Proceeds via Two Intermediates
Leah Pandiscia, PhD
July 28, 2017
A zinc bacteriochlorophyll-d analog possessing a fully π-conjugated porphyrin skeleton and an acrylate residue at the 17-position was prepared by chemical… Continue reading Self-aggregation of synthetic chlorophyll-c derivative and effect of C17-acrylate residue on bridging green gap in chlorosomal model
Leah Pandiscia, PhD
July 28, 2017
In silico screening of an in-house natural product database and confirmatory bioassays led to the identification of asperspiropene A (1) as… Continue reading Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The microbial transformation of glycyrrhetinic acid (1) by Cunninghamella blakesleana CGMCC 3.970 led to the production of five new metabolites (2–6). The… Continue reading Microbial transformation of glycyrrhetinic acid and potent neural anti-inflammatory activity of the metabolites
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The potential for infection by coronaviruses (CoVs) has become a serious concern with the recent emergence of Middle East respiratory… Continue reading Structural basis for dimerization and RNA binding of avian infectious bronchitis virus nsp9
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
An attempt of developing a chiral luminescent probe for amino acids was described. Two types of chiral iridium(III) complexes were… Continue reading Chiral phosphorescent probes for amino acids: hybrids of iridium(III) complexes with synthetic saponite
Leah Pandiscia, PhD
July 28, 2017
Bioguided isolation of the EtOH extract from the medicinal native plant, Ophryosporus charua, against Raphanus sativus, yielded three phenylpropanoids, charuol A [(Z)-4-((1S,2R)-3-acetoxy-1,2-dihydroxypropyl)phenyl)… Continue reading Phytotoxic phenylpropanoids isolated from Ophryosporus charua (Griseb.) Hieron.
Leah Pandiscia, PhD
July 28, 2017
A chemical investigation of the South China Sea sponge Agelas aff. nemoechinata yielded three pairs of new enantiotopic pyrrole alkaloids nemoechines A–C (1–3), one… Continue reading Alkaloids and polyketides from the South China Sea sponge Agelas aff.nemoechinata
Leah Pandiscia, PhD
July 28, 2017
We report a thermodynamic and structural analysis of six extensively simplified bovine pancreatic trypsin inhibitor (BPTI) variants containing 19–24 alanines… Continue reading Crystal structures of highly simplified BPTIs provide insights into hydration-driven increase of unfolding enthalpy
Leah Pandiscia, PhD
July 28, 2017
Streptococcus pneumoniae is a serious Gram-positive pathogen that can lead to an invasive pneumococcal disease with high mortality rate. Pneumococcal capsular… Continue reading Conjugation of PEG-hexadecane markedly increases the immunogenicity of pneumococcal polysaccharide conjugate vaccine
Leah Pandiscia, PhD
July 28, 2017
Five new 2-(2-phenylethyl)chromone derivatives (1–5), along with eleven known compounds (6–16) were isolated from Chinese agarwood. Their structures were elucidated… Continue reading Anti-inflammatory 2-(2-phenylethyl)chromone derivatives from Chinese agarwood
Leah Pandiscia, PhD
July 28, 2017
The novel property of reversible regulation of parallel type G-quadruplexes with moderate temperature changes was discovered in thermoresponsive hydrogels using… Continue reading Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel
Leah Pandiscia, PhD
July 28, 2017
Hipposponlachnins A (1) and B (2), possessing an unprecedented tetracyclo [9.3.0.02,8.03,7] tetradecane ring system, and the probable biogenetic precursor [3,… Continue reading Unusual Anti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017