Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Antibody light chain amyloidosis is a rare disease caused by fibril formation of secreted immunoglobulin light chains (LCs). The huge… Continue reading Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains
Leah Pandiscia, PhD
July 28, 2017
A novel 7-O-7′ type mesomeric neolignan, meso-asarolignan A (1), six pairs of new neolignan enantiomers, (±)-asarolignan B–G (2a/2b, 3a/3b, 4–6, 7a/7b), along with 16… Continue reading Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii
Leah Pandiscia, PhD
July 28, 2017
Three kinds of chiral BINOL-based polymers could be synthesized by polymerization in a Pd-catalyzed cross-coupling reaction. The resulting chiral polymers… Continue reading Circularly polarized luminescence based chirality transfer of the chiral BINOL moiety viarigid π-conjugation chain backbone structures
Leah Pandiscia, PhD
May 24, 2018
Leah Pandiscia, PhD
July 28, 2017
At the early stage of HIV infection, the low concentration of HIV components seriously hinders the diagnosis of this fatal… Continue reading Peptidic β-sheets induce Congo red-derived fluorescence to improve the sensitivity of HIV-1 p24 detection
Leah Pandiscia, PhD
July 28, 2017
Amyloidogenesis of proteins is of wide interest because amyloid structures are associated with many diseases, including Alzheimer’s and type II… Continue reading Surface shear viscosity as a macroscopic probe of amyloid fibril formation at a fluid interface
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Two new C2-symmetric N,N′-benzylated bis(amino amides) have been synthesised and their interaction with different transition metals studied using a variety of techniques… Continue reading Cu2+ recognition by N,N′-benzylated bis(amino amides)
Leah Pandiscia, PhD
July 28, 2017
This work describes functional and structural transitions of a novel protease isolated from Conidiobolus brefeldianus MTCC 5185 (Cprot), in detail using biophysical… Continue reading Conformational and functional transitions and in silico analysis of a serine protease from Conidiobolus brefeldianus (MTCC 5185)
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
In this paper we report the steady-state optical properties of a series of site-directed mutants in the Fenna-Matthews-Olson (FMO) complex… Continue reading Probing the excitonic landscape of the Chlorobaculum tepidum Fenna-Matthews-Olson (FMO) complex: a mutagenesis approach
Leah Pandiscia, PhD
July 28, 2017
STY3178 is a yfdX protein from Salmonella Typhi. yfdX proteins occur ubiquitously in a number of virulent bacteria but their cellular localization… Continue reading SDS induced dissociation of STY3178 oligomer: experimental and molecular dynamics studies
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The accumulation of amyloid β peptide(1–42) (Aβ(1–42)) in extracellular plaques is one of the pathological hallmarks of Alzheimer disease (AD).… Continue reading Amyloid–β 1–42 aggregation initiates its cellular uptake and cytotoxicity
Leah Pandiscia, PhD
July 28, 2017
Chiral pseudopeptide Cu(II) and Zn(II) complexes (1S/R and 2S/R, respectively), were obtained by a de novo synthetic strategy employing pseudopeptide synthons derived from R/S-2-amino-2-phenylethanol and N-methyliminodiacetic… Continue reading Synthesis of chiral R/S-pseudopeptide-based Cu(II) & Zn(II) complexes for use in targeted delivery for antitumor therapy: enantiomeric discrimination with CT-DNA and pBR322 DNA hydrolytic cleavage mechanism†
Leah Pandiscia, PhD
July 28, 2017
Antimicrobial peptides (AMPs) from amphibian skin are valuable template structures to find new treatments against bacterial infections. This work describes… Continue reading Structure and membrane interactions of the homodimeric antibiotic peptide homotarsinin
Leah Pandiscia, PhD
July 28, 2017
The DAPI structure has been modified by replacing the phenyl group with substituted phenyl or heteroaryl rings. Twelve amidines were… Continue reading Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties
Leah Pandiscia, PhD
July 28, 2017
The self-assembly behaviour of a library of tetra-amidated porphyrin molecules decorated with a variety of solubilizing wedges is investigated as… Continue reading Directing the self-assembly behaviour of porphyrin-based supramolecular systems
Leah Pandiscia, PhD
July 28, 2017