Candidates for the toxic molecular species in the expanded polyglutamine (polyQ) repeat diseases range from various types of aggregates to… Continue reading Backbone engineering within a latent β-hairpin structure to design inhibitors of polyglutamine amyloid formation
Leah Pandiscia, PhD
July 28, 2017
d-Form and l-form peptide nanofiber scaffolds can spontaneously form stable β-sheet secondary structures and nanofiber hydrogel scaffolds, and hold some promise… Continue reading Designer bFGF-incorporated d-form self-assembly peptide nanofiber scaffolds to promote bone repair
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
A room temperature ionic liquid (RT-IL) made by the negatively charged water soluble meso-tetrakis(4 sulfonatophenyl)porphyrin (TPPS4) and the positively charged… Continue reading Synthesis, Characterization and Aggregation Behaviour of Room Temperature Ionic Liquid Based on Porphyrin- trihexyl(tetradecyl)Phosphonium Adduct
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Surfactant-protein mixtures have attracted considerable research interest in recent years at the interface of chemical biology and medicinal chemistry. Herein,… Continue reading Unraveling the interaction of hemoglobin with a biocompatible and cleavable oxy-diester-functionalized gemini surfactant
Leah Pandiscia, PhD
July 28, 2017
A new 2-carboxy-dihydrostilbene glucoside, 2-carboxy-3,5,4′-trihydroxydihydrostilbene 3-O-β-d-glucopyranoside (1) and a new flavan diglycoside, (2S)-5,7,4′-trihydroxyflavan 7-O-β-d-apiofuranosyl-(1 → 6)-O-β-d-glucopyranoside (3) were isolated from the aerial… Continue reading 2-Carboxy-dihydrostilbene and flavan glycosides from Desmodium heterocarpon
Leah Pandiscia, PhD
July 28, 2017
Bispecific antibodies (BsAbs), with the ability to recognize two different epitopes simultaneously, offer remarkable advantages in bioassays, cancer therapy, biosensors,… Continue reading A detergent-based procedure for the preparation of IgG-like bispecific antibodies in high yield
Leah Pandiscia, PhD
July 28, 2017
Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocean and are important nitrogen source for bacteria. TMA monooxygenase (Tmm),… Continue reading Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide
Leah Pandiscia, PhD
July 28, 2017
Synthetic chiral polymers and helical polymers are finding increasing applications in catalysis and chiral recognition. Herein we have induced the… Continue reading Chiral Anion Triggered Helical Poly(ionic liquids)
Leah Pandiscia, PhD
July 28, 2017
Salmonella enterica species are enteric pathogens that cause severe diseases ranging from self-limiting gastroenteritis to enteric fever and sepsis in humans.… Continue reading Role of T3SS-1 SipD Protein in Protecting Mice against Non-typhoidal Salmonella Typhimurium
Leah Pandiscia, PhD
July 28, 2017
Thermosensing is critical for the expression of virulence genes in pathogenic bacteria that infect warm-blooded hosts. Proteins of the Hha-family,… Continue reading Graded Structural Polymorphism in a Bacterial Thermosensor Protein
Leah Pandiscia, PhD
July 28, 2017
The signaling of a G protein-coupled receptor (GPCR) is dictated by the complementary responsiveness of interacting intracellular effectors such as… Continue reading Construction of Structural Mimetics of the Thyrotropin Receptor Intracellular Domain
Leah Pandiscia, PhD
July 28, 2017
Two new dinuclear iridium (Ir) complexes bridged by a conjugated aromatic tppz ligand, (bhq)2Ir(tppz)Ir(bhq)2 (1) and (ppy)2Ir(tppz)Ir(ppy)2 (2) (bhq = benzo(h)quinolone, ppy… Continue reading Diiridium(III) complexes: luminescent probes and sensors for G-quadruplex DNA and endoplasmic reticulum imaging
Leah Pandiscia, PhD
July 28, 2017
Amyloid-β peptides (Aβ) fibrillation is the hallmark of Alzheimer’s disease (AD). However, it has been challenging to discover potent agents… Continue reading A resorcinarene for inhibition of Aβ fibrillation
Leah Pandiscia, PhD
July 28, 2017
Ferredoxins are protein mediators of biological electron-transfer reactions and typically contain either [2Fe–2S] or [4Fe–4S] clusters. Two ferredoxin homologues have… Continue reading Mapping cellular Fe–S cluster uptake and exchange reactions – divergent pathways for iron–sulfur cluster delivery to human ferredoxins
Leah Pandiscia, PhD
July 28, 2017
KRAS is mutated in >90% of pancreatic ductal adenocarcinomas. As its inactivation leads to tumour regression, mutant KRAS is considered an attractive target… Continue reading Lipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells
Leah Pandiscia, PhD
July 28, 2017
Four new quaternary phenanthroindolizidine alkaloids (1–4) were isolated from the whole plants of Tylophora atrofolliculata. Their structures were elucidated on the… Continue reading G-Quadruplex DNA-binding quaternary alkaloids from Tylophora atrofolliculata
Leah Pandiscia, PhD
July 28, 2017
Five new cadinane sesquiterpenoids, pholiotins A–E (1–5), and three known compounds, 11-hydroxy-1(10)-valencen-2-one (6), 8,11-dihydroxy-1(10)-eremophilen-2-one (7) and durgamone (8), were isolated… Continue reading New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp.
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017