Leah Pandiscia, PhD
July 28, 2017
The potential use of G-quadruplex (GQ) stabilizing small molecules as anti-cancer drugs has created a flurry of activity on various… Continue reading A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions
Leah Pandiscia, PhD
July 28, 2017
1,N6-Ethenoadenine (eA) and cytosine (C) are able to form two different metal-mediated base pairs. When the glycosidic bonds are arranged… Continue reading Relative strand orientation in a DNA duplex controls the nuclearity of a metal-mediated base pair
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Considering that the prevalence of antibiotic-resistant pathogenic bacteria is largely increasing, a thorough understanding of penicillin-binding proteins (PBPs) is of… Continue reading Biochemical and Structural Analysis of a Novel Esterase from Caulobacter crescentus related to Penicillin-Binding Protein (PBP)
Leah Pandiscia, PhD
July 28, 2017
The formation of distinct supramolecular assemblies, including a metastable species, is revealed for a lipophilic guanosine (G) derivative in solution… Continue reading Co-existence of distinct supramolecular assemblies in solution and in the solid state
Leah Pandiscia, PhD
July 28, 2017
An extended challenge is to control the supramolecular interaction and get information beyond molecules. An intriguing selfassembly of a perylene-3,4,9,10-tetracarboxylic… Continue reading Adaptive self-assembly behaviour restrained by supramolecular crystallization and molecular recognition
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The importance of Glucagon like peptide 1 (GLP-1) for metabolic control and insulin release sparked the evolution of genes mimicking… Continue reading Monotreme glucagon-like peptide-1 in venom and gut: one gene – two very different functions
Leah Pandiscia, PhD
July 28, 2017
Four new megastigmane glycosides, eucomegastigsides A-D (2, 3, 5 and 7), together with three known megastigmane glycosides, (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-[α-l-arabinopyranosyl-(l → 6)-β-d-glucopyranoside (1), foliasalacioside B1 (4) and… Continue reading Megastigmane glycosides from leaves of Eucommia ulmoidesOliver with ACE inhibitory activity
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the DNA repair… Continue reading Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c
Leah Pandiscia, PhD
July 28, 2017
A polypeptide coded as PGC was isolated from Arca subcrenata muscle using ion exchange, Sephadex G-50 gel chromatography and RP-HPLC. PGC was… Continue reading Purification and characterization of an antibacterial and anti-inflammatory polypeptide from Arca subcrenata
Leah Pandiscia, PhD
July 28, 2017
Membrane fusion is a highly regulated process that allows enveloped viruses to enter cells and replicate. Viral glycoproteins trigger membrane… Continue reading A biophysical characterization of the interaction of a hepatitis C virus membranotropic peptide with micelles
Leah Pandiscia, PhD
July 28, 2017
The development of peptide fusion inhibitors based on short synthetic peptides represents a promising option in the fight against HIV-1… Continue reading A cyclic GB virus C derived peptide with anti-HIV-1 activity targets the fusion peptide of HIV-1
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Here we enhanced the stability and biophysical properties of mRFP1 through a combination of canonical and non-canonical amino acid mutagenesis.… Continue reading Enhancing the biophysical properties of mRFP1 through incorporation of fluoroproline
Leah Pandiscia, PhD
July 28, 2017
The reovirus p10 fusion-associated small transmembrane (FAST) proteins are the smallest known membrane fusion proteins, and evolved specifically to mediate… Continue reading The p10 FAST protein fusion peptide functions as a cystine noose to induce cholesterol-dependent liposome fusion without liposome tubulation
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Four peptide sequences corresponding to the E1 protein of GBV-C: NCCAPEDIGFCLEGGCLV (P7), APEDIGFCLEGGCLVALG (P8), FCLEGGCLVALGCTICTD (P10) and QAGLAVRPGKSAAQLVGE (P18) were… Continue reading Physicochemical characterization of GBV-C E1 peptides as potential inhibitors of HIV-1 fusion peptide: Interaction with model membranes
Leah Pandiscia, PhD
July 28, 2017