Nucleophosmin (NPM1) is a multifunctional protein involved in a variety of biological processes including the pathogenesis of several human malignancies… Continue reading Insights into amyloid-like aggregation of H2 region of the C-terminal domain of nucleophosmin
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones, ineupatolides D and… Continue reading Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
c-Myc is a basic Helix-Loop-Helix Leucine Zipper (b-HLH-LZ) transcription factor deregulated in the majority of human cancers. As a heterodimer… Continue reading Miz-1 and Max Compete to Engage c-Myc: Implication for the Mechanism of Inhibition of c-Myc Transcriptional Activity by Miz-1
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Seven ferrocenyl naphthalene diimide (FND) ligands were synthesized. Each had a higher affinity for tetraplex DNA than for either single-… Continue reading Ferrocenyl naphthalene diimides as tetraplex DNA binders
Leah Pandiscia, PhD
July 28, 2017
Several polyene macrolides are potent antifungal agents that have severe side effects. Increased glycosylation of these compounds can improve water… Continue reading Engineered biosynthesis and characterisation of disaccharide-modified 8-deoxyamphoteronolides
Leah Pandiscia, PhD
July 28, 2017
The synthesis and investigation of molecular artificial motors have been subject to massive developments over the last years. One challenge… Continue reading A Light- and Electricity-Driven Molecular Pushing Motor
Leah Pandiscia, PhD
July 28, 2017
Human interleukin-3 (hIL-3) is a pleiotropic cytokine that stimulates the differentiation and proliferation of multipotent hematopoietic cells thus making it… Continue reading High-level expression and efficient refolding of therapeutically important recombinant human Interleukin-3 (hIL-3) in E. coli
Leah Pandiscia, PhD
July 28, 2017
Aqueous solutions of reline and glyceline, the most common deep eutectic solvents, were used as a medium for Catalase reaction.… Continue reading The effect of deep eutectic solvents on catalytic function and structure of bovine liver catalase
Leah Pandiscia, PhD
July 28, 2017
Glycosylation of DNA, proteins, lipids, etc. by reducing sugars, can lead to the formation of advanced glycation end products (AGEs).… Continue reading Fructosylation induced structural changes in mammalian DNA examined by biophysical techniques
Leah Pandiscia, PhD
July 28, 2017
We report a facile two-step strategy for grafting lanthanide complexes onto the surface of nanocrystalline cellulose-templated mesoporous silica films to… Continue reading Fabrication of free-standing fluorescent mesoporous silica films for detection of nitrobenzene
Leah Pandiscia, PhD
July 28, 2017
Uncariols A (1) and B (2), two new phenylpropanoid-substituted flavan-3-ols, and (±)-uncariols C (3a/3b) and D (4a/4b), two pairs of… Continue reading New phenylpropanoid-substituted flavan-3-ols and flavonols from the leaves of Uncaria rhynchophylla
Leah Pandiscia, PhD
July 28, 2017
Infection with oncogenic human papillomavirus induces deregulation of cellular redox homeostasis. Virus replication and papillomavirus-induced cell transformation require persistent expression… Continue reading Degenerate cysteine patterns mediate two redox sensing mechanisms in the papillomavirus E7 oncoprotein
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
In this study, we report the protective effects of linolenic acid towards the formation of early (HbA1c) and advanced glycation… Continue reading Linolenic acid prevents early and advanced glycation end-products (AGEs) modification of albumin
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Mutations in the C-terminus of human erythroid 5-aminolevulinate synthase (hALAS2), a pyridoxal 5′-phosphate (PLP)-dependent enzyme, are associated with two different… Continue reading Isoniazid inhibits human erythroid 5-aminolevulinate synthase: Molecular mechanism and tolerance study with four X-linked protoporphyria patients
Leah Pandiscia, PhD
July 28, 2017
Mycobacterium tuberculosis harbors proteasomes that recruit substrates for degradation through an ubiquitin-like modification pathway. Recently, a non-ATPase activator termed Bpa (bacterial proteasome… Continue reading Structural Analysis of the Bacterial Proteasome Activator Bpa in Complex with the 20S Proteasome
Leah Pandiscia, PhD
July 28, 2017