Guanine-rich DNA motifs can form non-canonical structures known as G-quadruplexes, whose role in tumorigenic processes makes them attractive drug-target candidates… Continue reading Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
A novel 21-residue peptide incorporating six fluorinated amino acids was prepared. It was designed to fold into an amphiphilic alpha… Continue reading Membrane Assembly and Ion Transport Ability of a Fluorinated Nanopore
Leah Pandiscia, PhD
July 28, 2017
Cartilage acidic protein1 (CRTAC1) is an extracellular matrix protein of chondrogenic tissue in humans and its presence in bacteria indicate… Continue reading Cartilage Acidic Protein 1 (CRTAC1), a new member of the beta-propeller protein family with amyloid propensity
Leah Pandiscia, PhD
July 28, 2017
The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl… Continue reading Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?
Leah Pandiscia, PhD
July 28, 2017
In order to design improved chiral ruthenium catalysts for asymmetric olefin metathesis, enantiomeric catalysts incorporating C1-symmetric N-Heterocyclic carbenes (NHC) ligands with syn-related substituents… Continue reading Enantiopure C1-symmetric N-Heterocyclic Carbene Ligands from Desymmetrized meso-1,2-Diphenylethylenediamine: Application in Ruthenium-Catalyzed Olefin Metathesis
Leah Pandiscia, PhD
July 28, 2017
The widespread use of organic solvents in industrial processes has focused in recent years on the utility of “green” solvents… Continue reading Hemin-utilizing G-quadruplex DNAzymes are strongly active in organic co-solvents
Leah Pandiscia, PhD
July 28, 2017
Cold-active lipases have emerged as an important class of biocatalysts for chemical and food industries due to their high efficiency… Continue reading Conversion of a Monascus ruber esterase into a lipase by disrupting a salt bridge
Leah Pandiscia, PhD
July 28, 2017
A system based on two designed peptides, namely the cationic peptide K, (KIAALKE)3, and its complementary anionic counterpart called peptide… Continue reading A Coiled-Coil Peptide Shaping Lipid Bilayers upon Fusion
Leah Pandiscia, PhD
July 28, 2017
A coacervate extraction method, based on hexafluoroisopropanol (HFIP)-induced catanionic surfactants and coupled with a back-extraction procedure, was developed for separation… Continue reading Hexafluoroisopropanol-induced catanionic-surfactants-based coacervate extraction for analysis of lysozyme
Leah Pandiscia, PhD
July 28, 2017
Tropoelastin, as the monomer unit of elastin, assembles into elastic fibers that impart strength and resilience to elastic tissues. Tropoelastin… Continue reading Targeted Modulation of Tropoelastin Structure and Assembly
Leah Pandiscia, PhD
July 28, 2017
L-asparaginase (L-ASNase) (EC 3.5.1.1) is an important enzyme for the treatment of acute lymphoblastic leukaemia. Currently, the enzyme is obtained… Continue reading Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity
Leah Pandiscia, PhD
July 28, 2017
Phenylcarbamate derivatives of amylose and β-cyclodextrin show excellent chiral recognition when used as chiral stationary phases (CSPs) for high-performance liquid… Continue reading Development of Amylose- and β-Cyclodextrin-Based Chiral Fluorescent Sensors Bearing Terthienyl Pendants
Leah Pandiscia, PhD
July 28, 2017
Two nonionic detergents, Triton X-100 (TX-100) and n-dodecyl-β-d-maltoside (DDM) were tested for their ability to affect lysozyme amyloid aggregation. We have… Continue reading Interaction of nonionic detergents with the specific sites of lysozyme amyloidogenic region − inhibition of amyloid fibrillization
Leah Pandiscia, PhD
July 28, 2017
Multispectroscopic techniques were used to investigate the interaction of S-allyl cysteine (SAC) from garlic with human serum albumin (HSA). UV–Vis… Continue reading Study on the interaction of bioactive compound S-allyl cysteine from garlic with serum albumin
Leah Pandiscia, PhD
July 28, 2017
When mixtures of D2O/DCl are used to foster the self-assembly formation of TPPS4 porphyrin J-aggregates in aqueous solutions, an inverse… Continue reading Inverse kinetic and equilibrium isotopic effect on self-assembly and supramolecular chirality of porphyrin J-aggregates
Leah Pandiscia, PhD
July 28, 2017
Asymmetric synthesis of chiral amines by amine dehydrogenases (AmDH), which catalyzed reductive amination of ketones with high enantioselectivity, is an… Continue reading Encapsulation of amine dehydrogenase in hybrid titania nanoparticles by polyethylenimine coating and templated biomineralization
Leah Pandiscia, PhD
July 28, 2017