Deposition of amyloid fibers has been a common pathological event in number of neurodegenerations such as Alzheimer’sdisease, Parkinson disease, Prion… Continue reading Nano Zinc Oxide Inhibits Fibrillar Growth and Suppresses Cellular Toxicity of Lysozyme Amyloid
Leah Pandiscia, PhD
July 28, 2017
Protein-side-chain protonation, coupled to conformational rearrangements, is one way of regulating physiological function caused by changes in protein environment. Specifically,… Continue reading The pH-Dependent Trigger in Diphtheria Toxin T Domain Comes with a Safety Latch
Leah Pandiscia, PhD
July 28, 2017
With the advent of newer luminescent nanoparticles (NPs) for bioimaging applications, their complex interactions with the individual biomolecules need to… Continue reading Insights into the Thermodynamics of Polymer Nanodot–Human Serum Albumin Association: A Spectroscopic and Calorimetric Approach
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The Pfam PF04536 TPM_phosphatase family is a broadly conserved family of domains found across prokaryotes, plants and invertebrates. Despite having… Continue reading Structural and functional characterization of a cold adapted TPM-domain with ATPase/ADPase activity
Leah Pandiscia, PhD
July 28, 2017
In addition to intravenous injections (i.v.), topical dosing of doxorubicin hydrochloride (DOX) has also been the focus of cancer treatment… Continue reading Nano-rods of doxorubicin with poly(L-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment
Leah Pandiscia, PhD
July 28, 2017
The gelation behavior of mixtures of sodium deoxycholate (NaDC) and glutathione (GSH) in water is investigated. The system exhibits a… Continue reading Hydrogels of Super-Long Helices to Synthesize Hybrid Ag-Helical Nanomaterials
Leah Pandiscia, PhD
July 28, 2017
Human lysozyme is homologous in the three-dimensional structure to hen lysozyme and the latter is commonly used to understand folding… Continue reading A Comparative Study of Fibrillation Kinetics of Two Homologous Proteins under Identical Solution Condition
Leah Pandiscia, PhD
July 28, 2017
This study aimed to improve the thermostability of endo-1,4-β-xylanase (afxynG1) from Aspergillus fumigatus RT-1 using error-prone PCR. Since the wild type enzyme has… Continue reading Thermostability enhancement of xylanase Aspergillus fumigatus RT-1
Leah Pandiscia, PhD
July 28, 2017
Formation of ruthenium(II) complexes of the type [RuH(CO)(PPh3)2(L)] (where L = N-Substituted 9-ethyl carbazole thiosemicarbazone ligands) has been described from the reactions… Continue reading Ru(II) carbazole thiosemicarbazone complexes with four membered chelate ring: Synthesis, molecular structures and evaluation of biological activities
Leah Pandiscia, PhD
July 28, 2017
We have studied the intra- and inter-molecular chirogenesis events on a family of chiral bisporphyrin hosts H1-H3. The three pairs of… Continue reading Intramolecular chirality induction and intermolecular chirality modulation in BINOL bridged bisporphyrin hosts
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
A heme-dependent peroxidase (HDP) catalyzes the ortho-hydroxylation of l-tyrosine to l-3,4-dihydroxyphenylalanine (l-DOPA) in the presence of hydrogen peroxide. l-DOPA can be used for… Continue reading Enhancing the Enzymatic Activity of a Heme-Dependent Peroxidase through Genetic Modification
Leah Pandiscia, PhD
July 28, 2017
Here, we present the design, synthesis and characterization of a novel photocaged glutamine derivative on the side-chain of glutamine and… Continue reading A novel caged-glutamine derivative as a tool to control the assembly of glutamine-containing amyloidogenic peptides
Leah Pandiscia, PhD
July 28, 2017
Acyclic serinol derivatives are useful scaffolds for tethering dyes within DNA duplexes. Here we synthesized an inverse L-threoninol (iL-threoninol) scaffold… Continue reading Effect of Methyl Group on Acyclic Serinol Scaffold for Tethering Dyes on DNA Duplex stability
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The facultative intracellular pathogen Listeria monocytogenes causes listeriosis, a rare but life-threatening disease. Host cell entry begins with activation of… Continue reading MET-activating Residues in the B-repeat of the Listeria monocytogenes Invasion Protein InlB
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017