To overcome the hurdles of cisplatin, majorly its toxicity and resistance, there has been extensive search for alternative anti-cancer metal-based… Continue reading Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents
Leah Pandiscia, PhD
July 28, 2017
Ice nucleation protein (INP) with its functional domain consisting of multiple 48-residue repeat units effectively induces super-cooled water into ice.… Continue reading Biophysical characterization of soluble Pseudomonas syringae ice nucleation protein InaZ fragments
Leah Pandiscia, PhD
July 28, 2017
Nine dimeric xanthanolides, pungiolides F–N, and five known analogues, pungiolides A–E, were isolated from fruits of Xanthium chinense. Their structures were… Continue reading Cytotoxic dimeric xanthanolides from fruits of Xanthium chinense
Leah Pandiscia, PhD
July 28, 2017
The spliceosomal B complex-specific protein Prp38 forms a complex with the intrinsically unstructured proteins MFAP1 and Snu23. Our binding and… Continue reading Scaffolding in the Spliceosome via Single α Helices
Leah Pandiscia, PhD
July 28, 2017
Dentin collagen can be modified by some plant-derived flavonoids to improve properties of dentin organic matrix. Hesperidin (HPN), a hesperetin-7-O-rutinoside… Continue reading Hesperidin interaction to collagen detected by physico-chemical techniques
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
There is a significant need for developing compounds that kill Cryptococcus neoformans, the fungal pathogen that causes meningoencephalitis in immunocompromised individuals.… Continue reading Mode of Action of a Designed Antimicrobial Peptide: High Potency against Cryptococcus neoformans
Leah Pandiscia, PhD
July 28, 2017
Eight new flavonoid dimers, named cochinchinenins I–M (1–5), including three pairs of enantiomers (1a/1b–3a/3b) and two optically pure flavonoid dimers… Continue reading Flavonoid dimers from the total phenolic extract of Chinese dragon’s blood, the red resin of Dracaena cochinchinensis
Leah Pandiscia, PhD
July 28, 2017
Cisplatin is a widely used anticancer drug for the treatment of a variety of human malignancies. It has been reported… Continue reading Cisplatin Preferentially Binds to Zinc Finger Proteins Containing C3H1 or C4 Motif
Leah Pandiscia, PhD
July 28, 2017
Polyelectrolyte complexes (PECs) have a broad range of promising applications as soft materials due to their self-assembly and diversity of… Continue reading Directing the phase behavior of polyelectrolyte complexes using chiral patterned peptides
Leah Pandiscia, PhD
July 28, 2017
The S100 proteins are a large family of signaling proteins that play critical roles in biology and disease. Many S100… Continue reading Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Protein biogenesis is tightly linked to protein quality control (PQC). The role of PQC machinery in recognizing faulty polypeptides is… Continue reading Recognition of enzymes lacking bound cofactor by protein quality control
Leah Pandiscia, PhD
July 28, 2017
Extracts of Alzheimer’s disease (AD) brain that contain what appear to be SDS-stable amyloid β-protein (Aβ) dimers potently block LTP… Continue reading The aggregation paths and products of Aβ42 dimers are distinct from Aβ42 monomer
Leah Pandiscia, PhD
July 28, 2017
DNGR‐1 is receptor expressed by certain dendritic cell (DC) subsets and by DCprecursors in mouse. It possesses a C‐type lectin‐like domain… Continue reading A pH‐ and ionic strength‐dependent conformational change in the neck region regulates DNGR‐1 function in dendritic cells
Leah Pandiscia, PhD
July 28, 2017
Resveratrol is one of the most widely studied bioactive plant polyphenols which possesses anticancer properties. Previously we have reported synthesis,… Continue reading A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells
Leah Pandiscia, PhD
July 28, 2017
Accumulation and aggregation of amyloid β-protein (Aβ) play an important role in the pathogenesis of Alzheimer’s disease. There has been… Continue reading Hematoxylin Inhibits Amyloid β-Protein Fibrillation and Alleviates Amyloid-Induced Cytotoxicity
Leah Pandiscia, PhD
July 28, 2017
Coomassie Brilliant Blue interacts with proteins and even though the interactions exhibit variation due to the amino acid content, reported… Continue reading A Dynamic Interaction of Coomassie Dye with the Glycine Transporters N-termini
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017