G-rich sequences can adopt four-stranded helical structures, called G-quadruplexes, that self-assemble around monovalent cations like sodium (Na+) and potassium (K+).… Continue reading A Parallel Stranded G-Quadruplex Composed of Threose Nucleic Acid (TNA)
Leah Pandiscia, PhD
July 28, 2017
The oligomerization and aggregation of amyloid β (Aβ) play central role in the pathogenesis of Alzheimer’s disease (AD). Molecular binding… Continue reading Antiamyloidogenic Activity of Aβ42-Binding Peptoid in Modulating Amyloid Oligomerization
Leah Pandiscia, PhD
July 28, 2017
Hydrogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases from hypertension to stroke, diabetes and… Continue reading Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production
Leah Pandiscia, PhD
July 28, 2017
The most widespread Plasmodium species, Plasmodium vivax, poses a significant public health threat. An effective vaccine is needed to reduce global malaria burden.… Continue reading A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The present study reported for the first time covalent immobilization of protocatechuate 3,4-dioxygenase (3,4-POD) onto functionalized multi-walled carbon nanotubes (F-MWCNT)… Continue reading Highly Efficient and Stable Novel NanoBiohybrid Catalyst to Avert 3,4-Dihydroxybenzoic Acid Pollutant in Water
Leah Pandiscia, PhD
July 28, 2017
Antimicrobial peptides (AMPs) play a key role in the defence mechanism of living organisms against microbial pathogens, displaying both bactericidal… Continue reading Effects of Aib residues insertion on the structural–functional properties of the frog skin-derived peptide esculentin-1a(1–21)NH2
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Studying amyloid associated neurodegenerative diseases is an active area of research. Cure for these diseases are still to be discovered.… Continue reading Fibrillogenesis of human serum albumin in the presence of levodopa – spectroscopic, calorimetric and microscopic studies
Leah Pandiscia, PhD
July 28, 2017
Nanoparticle delivery systems have been extensively investigated for targeted delivery of anticancer drugs over the past decades. However, it is… Continue reading Self-assembled mirror DNA nanostructures for tumor-specific delivery of anticancer drugs
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Matrix metalloproteinase 7 (MMP7/matrilysin-1) has been implicated in many pathological conditions, such as in cancer and inflammatory diseases; therefore, MMP7… Continue reading Biochemical characterization and zinc binding group (ZBGs) inhibition studies on the catalytic domain of MMP7 (cdMMP7)
Leah Pandiscia, PhD
July 28, 2017
Proteins are often functionally dependent on conformational changes that allow them to sample structural states that are sparsely populated in… Continue reading Urea-Dependent Adenylate Kinase Activation following Redistribution of Structural States
Leah Pandiscia, PhD
July 28, 2017
We report the synthesis, spectroscopy, and the DNA binding properties of a biocompatible, water-soluble, polycationic two-photon absorbing anthracenyl derivative (Ant-PIm)… Continue reading Unravelling the binding mechanism of a poly(cationic) anthracenyl fluorescent probe with high affinity towards ds-DNA
Leah Pandiscia, PhD
July 28, 2017
Light-dependent protochlorophyllide oxidoreductase (POR, E.C. 1.3.1.33) is a plant enzyme that directly needs light to conduct a biochemical reaction. In… Continue reading Insight into the oligomeric structure of PORA from A. thaliana
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Protein–protein interactions (PPIs) are increasingly important targets for drug discovery. Efficient fragment-based drug discovery approaches to tackle PPIs are often… Continue reading Engineering archeal surrogate systems for the development of protein–protein interaction inhibitors against human RAD51
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017