Glycoengineering of mAbs has become common practice in attempts to generate the ideal mAb candidate for a wide range of… Continue reading Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity
Leah Pandiscia, PhD
July 28, 2017
The hallmark feature of Mycobacterium tuberculosis (M.tb) the causative agent of human tuberculosis, is its complex lipid rich cell wall comprised primarily… Continue reading The Mycobacterium tuberculosis desaturase DesA1 (Rv0824c) is a Ca2+ binding protein
Leah Pandiscia, PhD
July 28, 2017
Cell polarity arises from a combination of interactions between biological molecules, such as activation, inhibition, and positive or negative feedback… Continue reading In vitro reconstitution of a membrane switch mechanism for the polarity protein LGL
Leah Pandiscia, PhD
July 28, 2017
The intake of Narthecium ossifragum, commonly known as bog asphodel, has been associated with toxic effects observed in sheep for centuries.… Continue reading Toxic aromatic compounds from fruits of Narthecium ossifragum L.
Leah Pandiscia, PhD
July 28, 2017
Two structural Ca2+ (proximal and distal) is known to be important for ligninolytic peroxidases. However, few studies toward impact of residues… Continue reading Insight into the impact of two structural calcium ions on the properties of Pleurotus eryngii versatile ligninolytic peroxidase
Leah Pandiscia, PhD
July 28, 2017
Gelatin films plasticized with different glycerol contents (0–40%) were cross-linked using transglutaminase (TGase). Unmodified films were prepared as controls. Cross-linking… Continue reading Study of combined effects of glycerol and transglutaminase on properties of gelatin films
Leah Pandiscia, PhD
July 28, 2017
In this study, the effect of ball-milling (BM, Mixer Mill MM 400) treatments on the physicochemical properties of soybean protein… Continue reading Ball-milling changed the physicochemical properties of SPI and its cold-set gels
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Engineering protein hydrogels with dynamically tunable mechanical and physical properties is of great interests due to their potential applications in… Continue reading Metal chelation dynamically regulates the mechanical properties of engineered protein hydrogels
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Protein aggregation is linked to a growing list of diseases, but it is also an intrinsic property of polypeptides, because… Continue reading Amyloid Formation by Human Carboxypeptidase D Transthyretin-like Domain under Physiological Conditions
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Harmane and norharmane are representative members of the large group of natural β-carboline alkaloids featured with diverse pharmacological activities. In… Continue reading Fatty Acid Modulated Human Serum Albumin Binding of the β-Carboline Alkaloids Norharmane and Harmane
Leah Pandiscia, PhD
July 28, 2017
Dementia with Lewy bodies (DLB), Parkinson’s disease (PD) and multiple system atrophy are characterized by the deposition of disease-associated α-synuclein. In the present… Continue reading Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread
Leah Pandiscia, PhD
July 28, 2017
Glycopolymers carrying sulfated saccharides with modest sugar contents (11% and 28%) were found to suppress the formation of amyloid fibrils… Continue reading Inhibition of Alzheimer Amyloid Aggregation with Sulfated Glycopolymers
Leah Pandiscia, PhD
July 28, 2017
The major protein component of the amyloid deposition in Alzheimer’s disease is a 39–43 residue peptide, amyloid β (Aβ). Aβ is toxic to… Continue reading Time-Dependent DNA Condensation Induced by Amyloid β-Peptide
Leah Pandiscia, PhD
July 28, 2017
Prolonged exposure of hen egg white lysozyme to near-UV light results in an unusual fluctuating and red shift of fluorescence… Continue reading Photoexcitation of tryptophan groups induced reduction of disulfide bonds in hen egg white lysozyme
Leah Pandiscia, PhD
July 28, 2017
Ample evidence suggests that almost all polypeptides can either adopt a native structure (folded or intrinsically disordered) or form misfolded… Continue reading Binding with Nucleic Acids or Glycosaminoglycans Converts Soluble Protein Oligomers to Amyloid
Leah Pandiscia, PhD
July 28, 2017