Leah Pandiscia, PhD
July 28, 2017
Recently, the smallest bioluminescent protein (MW: 19.9 kDa), Gaussia luciferase (GLuc), has been isolated from the marine copepod Gaussia princeps and has attracted much attention… Continue reading Biophysical characterization of highly active recombinantGaussia luciferase expressed in Escherichia coli
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Reported here is a laboratory in vitro evolution (LIVE) experiment based on an artificially expanded genetic information system (AEGIS). This experiment delivers… Continue reading Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen
Leah Pandiscia, PhD
July 28, 2017
Guanine-rich oligonucleotides are capable of forming tetrahelical structures known as G-quadruplexes with interesting biological properties. We have investigated the effects… Continue reading The effect of l-thymidine, acyclic thymine and 8-bromoguanine on the stability of model G-quadruplex structures
Leah Pandiscia, PhD
July 28, 2017
The E6 protein from human papillomavirus (HPV) plays an important role during productive infection and is a potential drug target.… Continue reading Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions
Leah Pandiscia, PhD
July 28, 2017
We introduce a new experimental technique referred to as Ellipsometric Raman Spectroscopy (ERS) to quantify the Raman Optical Activity (ROA)… Continue reading Ellipsometric Raman Spectroscopy
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
FeS-clusters are utilized by numerous proteins within several biological pathways essential for life. In eukaryotes, the primary FeS-cluster production pathway… Continue reading In vitro characterization of a novel Isu homologue from Drosophila melanogaster for de novo FeS-cluster formation.
Leah Pandiscia, PhD
July 28, 2017
Nitroaromatic compounds are typically toxic and resistant to degradation. Bradyrhizobium species strain JS329 metabolizes 5-nitroanthranilic acid (5NAA), which is a molecule secreted… Continue reading Enzymatic hydrolysis by transition-metal-dependent nucleophilic aromatic substitution
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Bulky cations are used to develop nucleic-acid-based technologies for medical and technological applications in which nucleic acids function under nonaqueous… Continue reading Thermal Stability of RNA Structures with Bulky Cations in Mixed Aqueous Solutions
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The present work is devoted to reveal physicochemical properties and several biological actions of a new thiosemicarbazone (NTSC) derived from… Continue reading Coordination ability and biological activity of a naringenin thiosemicarbazone
Leah Pandiscia, PhD
July 28, 2017
In this paper we present lomefloxacin’s (HLm, 2nd generation fluoroquinolone antibiotic agent) organic and inorganic derivatives: aminomethyl(diphenyl)phosphine (PLm), its oxide… Continue reading New copper(I) complexes bearing lomefloxacin motif: Spectroscopic properties, in vitro cytotoxicity and interactions with DNA and human serum albumin
Leah Pandiscia, PhD
July 28, 2017
In the present work, the synthesis, characterization and DNA binding study of water-soluble γ-Fe2O3@SiO2-nicotinamide magnetic nanoparticles (MNPs) were undertaken. The… Continue reading Functionalization of Fe3O4@SiO2 magnetic nanoparticles with nicotinamide and in vitro DNA interaction
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
trans-BMPyP induced the B-Z transition for alternated AT oligonucleotides as it was evident by inversed CD spectrum. The transition occurred… Continue reading Length and sequence effect on the B-Z transition of [d(A-T)n]2 oligonucleotide induced by a cationic porphyrin
Leah Pandiscia, PhD
July 28, 2017
Quaternary amine of diethylaminoethyl rosin ester (QRMAE), chemically synthesized by rosin modified biocompatible cationic surfactant, has various biological applications in… Continue reading Anti-aggregation property of thymoquinone induce by copper-nanoperticles: A biophysical approach
Leah Pandiscia, PhD
July 28, 2017