PEGylation has successfully improved the pharmacological properties of therapeutic proteins. However, polyethylene glycol (PEG) has been burdened by immunogenicity that… Continue reading Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins
Leah Pandiscia, PhD
July 28, 2017
Toonasinemines A-K (1–12), twelve new azadirone- and gedunin-type limonoids with eight-classes of modified furan rings, were isolated from the root… Continue reading Limonoids with modified furan rings from root barks of Toona sinensis
Leah Pandiscia, PhD
July 28, 2017
Septins are GTP-binding proteins that are highly conserved among eukaryotes and which are usually membrane-associated. They have been linked to… Continue reading Biophysical dissection of schistosome septins: insights into oligomerization and membrane binding
Leah Pandiscia, PhD
July 28, 2017
Here, we for the first time demonstrated thioflavin T (ThT) as an efficient fluorescent ligand for 27-mer ATP-binding aptamer (ABA27),… Continue reading Thioflavin T behaves as an efficient fluorescent ligand for label-free ATP aptasensor
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Eight closely biogenetically-related aromadendrane-type sesquiterpenoids, six of them new, scedogiines A–F (1–3, 6–8), together with a new polyketide scedogiine G (9)… Continue reading Discovery of aromadendrane anologues from the marine-derived fungus Scedosporium dehoogiiF41-4 by NMR-guided isolation
Leah Pandiscia, PhD
July 28, 2017
Prefibrillar amyloid aggregates of proteins are known as cytotoxic species and a common pathogenic factor of many degenerative diseases. The… Continue reading Formation of Lamellar Micelle-like Oligomers and Membrane Disruption Revealed by the Study of Short Peptide hIAPP18-27
Leah Pandiscia, PhD
July 28, 2017
The emergence of antibiotic resistance in microbial pathogens requires the identification of new antibacterial drugs. The biosynthesis of methionine is… Continue reading Characterization of C-S Lyase from C. diphtheriae: A Possible Target for New Antimicrobial Drugs
Leah Pandiscia, PhD
July 28, 2017
In recent years, there has been increased interest in bacterial methionine biosynthesis enzymes as antimicrobial targets because of their pivotal… Continue reading Role of active-site residues Tyr55 and
Tyr114 in catalysis and substrate specificity
of Corynebacterium diphtheriae C-S lyase
Leah Pandiscia, PhD
July 28, 2017
Microtubule affinity regulatory kinase 4 (MARK4) belongs to the family of AMP-activated protein kinase. It phosphorylates microtubule associated proteins at… Continue reading Ubiquitin-associated domain of MARK4 provides stability at physiological pH
Leah Pandiscia, PhD
July 28, 2017
A transition of amyloidogenic protein by alternative folding pathway under certain conditions leads to the formation of protease resistant amyloid… Continue reading In vitro and in vivo insulin amyloid degradation mediated by Serratiopeptidase
Leah Pandiscia, PhD
July 28, 2017
Imatinib mesylate (Imt) is a tyrosine kinase inhibitor mainly used in the treatment of Philadelphia chromosome-positive chronic myelogenous leukemia (pH + CML).… Continue reading Interaction of imatinib mesylate with human serum transferrin: The comparative spectroscopic studies
Leah Pandiscia, PhD
July 28, 2017
DNA damage by endogenous/exogenous chemicals and ionizing radiation results in the formation of abasic sites, alkylation products, oxidative lesions and… Continue reading Effect of conformation of the Arylamine-DNA adduct on the sensitivity of [Ru(phen)2(dppz)]2 + complex
Leah Pandiscia, PhD
July 28, 2017
The interaction of Deltamethrin (DM) with human serum albumin (HSA) under the condition of simulating human blood pH environment (pH = 7.4)… Continue reading Investigation of the interaction of deltamethrin (DM) with human serum albumin by multi-spectroscopic method
Leah Pandiscia, PhD
July 28, 2017
Armadillo repeat proteins (ArmRP) recognize their target peptide in extended conformation and bind, in a first approximation, two residues per… Continue reading Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Peptides play an important role in metabolic regulation. In this study, one primary peptide derived from ostrich egg white protein… Continue reading Bioactive and ACE binding properties of three synthetic peptides assessed by various spectroscopy techniques
Leah Pandiscia, PhD
July 28, 2017