An efficient method to deliver active proteins into cytosol is highly desirable to advance protein-based therapeutics. Arginine-rich cell-penetrating peptides (RPPs)… Continue reading An Efficient Mini-Transporter for Cytosolic Protein Delivery
Leah Pandiscia, PhD
July 28, 2017
Naturally occurring, pharmacologically active peptides constrained with covalent crosslinks generally have shapes that have evolved to fit precisely into binding… Continue reading Accurate de novo design of hyperstable constrained peptides
Leah Pandiscia, PhD
July 28, 2017
In order to model the metal ion binding capabilities of high molecular mass components of blood the interaction between [(η6-p-cym)Ru(H2O)3]2+ and… Continue reading Complex formation between [(η6-p-cym)Ru(H2O)3]2+ and oligopeptides containing three histidyl moieties
Leah Pandiscia, PhD
July 28, 2017
We demonstrated that the circular dichroism (CD) exciton chirality method based on the supramolecular interactions of meso-tetra(4-sulfonatophenyl)porphyrin (MTPPS4, M =… Continue reading Absolute Configuration Determination of Side Chains of Basic Amino Acid Residues Using Water-Soluble Porphyrins-Based Exciton Chirality Method
Leah Pandiscia, PhD
July 28, 2017
Biomolecule promoted helical polypeptides and their structural diversity towards external/internal stimuli is an interesting research area to the material science… Continue reading POSS semitelechelic Aβ17–19 peptide initiated helical polypeptides and their structural diversity in aqueous medium
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Isotopically labeled proteins have been used as internal standards for mass spectrometry (MS)-based absolute protein quantification. Although this approach can… Continue reading Preparation of soluble isotopically labeled human growth hormone produced in Escherichia coli
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The binding behavior of nanoparticle with proteins determines its biocompatibility. This study reports the interaction of ten different biomolecules (proteins-BSA,… Continue reading Role of PAMAM-OH dendrimers against the fibrillation pathway of biomolecules
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
New chiral L-/d-valine-quercetin diorganotin(IV) complexes [(CH3)2Sn(Q)(val)] 1L/D, [(C6H5)2Sn(Q)(val)] 2L/D, were synthesized and thoroughly characterized by elemental analysis, mass spectrometry, IR, 1H NMR, 119Sn NMR… Continue reading Human Topoisomerase I mediated cytotoxicity profile of L-valine-quercetin diorganotin(IV) antitumor drug entities
Leah Pandiscia, PhD
July 28, 2017
The molecular chaperone Hsp90 and its cofactor Cdc37 are required for the stability of protein kinases in the cellular environment.… Continue reading Nucleotide-Free sB-Raf is Preferentially Bound by Hsp90 and Cdc37 In Vitro
Leah Pandiscia, PhD
July 28, 2017
Insertion of a nascent membrane protein segment by the translocon channel into the bilayer is naturally promoted by high segmental… Continue reading Hydrophobic clusters raise the threshold hydrophilicity for insertion of transmembrane sequences in vivo
Leah Pandiscia, PhD
July 28, 2017
A series of binuclear ruthenium(II)–polypyridyl complexes of the type [Ru2(N-N)4(BPIMBp)]4+, in which N-N is 2,2′-bipyridine (bpy; 1), 1,10-phenanthroline (phen; 2),… Continue reading Honeycomb-like Ordered Assembly of DNA Induced by Flexible Binuclear Ruthenium(II)–Polypyridyl Complexes
Leah Pandiscia, PhD
July 28, 2017
Recombinant human GM-CSF (rhGM-CSF) from yeast has been clinically applied to immunosuppressed patients. The production of suspension-cultured rice-cell-derived rhGM-CSF (rrhGM-CSF),… Continue reading O-glycans and O-glycosylation sites of recombinant human GM-CSF derived from suspension-cultured rice cells, and their structural role
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
With the capability to inhibit the formation of amyloid β peptides (Aβ) fibril, dopamine (DA) and other catechol derivatives have… Continue reading Complicated function of dopamine in Aβ-related neurotoxicity: Dual interactions with Tyr10 and SNK(26–28) of Aβ
Leah Pandiscia, PhD
July 28, 2017
New chiral reduced Schiff base ligands, L1 and L2 derived from l–/d-histidine and terepthaldehyde, and their Cu(II) and Ni(II) dinuclear complexes 1 & 2 (a and b) were synthesized and thoroughly… Continue reading In vitro DNA binding profile of enantiomeric dinuclear Cu(II)/Ni(II) complexes derived from l–/d–histidine–terepthaldehyde reduced Schiff base as potential chemotherapeutic agents
Leah Pandiscia, PhD
July 28, 2017