Reticulons (RTNs) are a class of endoplasmic reticulum (ER) membrane proteins that are capable of maintaining high membrane curvature, thus… Continue reading A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon
Leah Pandiscia, PhD
July 28, 2017
HdeA and HdeB are essential chaperones for many Gram-negative enteric bacteria to survive acid stress. How they cooperate to protect… Continue reading Comparative proteomics reveal distinct chaperone–client interactions in supporting bacterial acid resistance
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The self-assembly behavior of polyoxometalates (PMs) and facial-like cationic peptides carrying lysine residues were systematically investigated. Circular dichroism and UV/Vis… Continue reading Engineering the Ionic Self-Assembly of Polyoxometalates and Facial-Like Peptides
Leah Pandiscia, PhD
July 28, 2017
Supramolecular gelation provides an efficient way of fabricating functional soft materials with various nanostructures. Amphiphiles containing naphthyl group and dialkyl… Continue reading Dynamic Evolution of Coaxial Nanotoruloid in the Self-Assembled Naphthyl-containing L-Glutamide
Leah Pandiscia, PhD
July 28, 2017
Aggregation of denatured or unfolded proteins establishes a large energy barrier to spontaneous recovery of protein form and function following… Continue reading The Pentablock Amphiphilic Copolymer T1107 Prevents Aggregation of Denatured and Reduced Lysozyme
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
We demonstrate that chiral magnesium nanoparticles show remarkable plasmonic extinction- and chiroptical-effects in the ultraviolet region. The Mg nanohelices possess… Continue reading Magnesium plasmonics for UV applications and chiral sensing
Leah Pandiscia, PhD
July 28, 2017
Lunasin is a 43 amino acid peptide with anti-cancer, antioxidant, anti-inflammatory andcholesterol-lowering properties. Although the mechanism of action of lunasin has been characterized to some extent, its… Continue reading Lunasin is a redox sensitive intrinsically disordered peptide with two transiently populated α-helical regions
Leah Pandiscia, PhD
July 28, 2017
Proline dehydrogenase (ProDH) is a ubiquitous flavoenzyme involved in the biosynthesis of l-glutamate. ProDH is of interest for biocatalysis because the… Continue reading A more polar N-terminal helix releases MBP-tagged Thermus thermophilus proline dehydrogenase from tetramer-polymer self-association
Leah Pandiscia, PhD
July 28, 2017
Two new benzaldehyde derivatives, named 3′-OH-tetrahydroauroglaucin (1) and(3′S*,4′R*)-6-(3′,5-epoxy-4′-hydroxy-1′-heptenyl)-2-hydroxy-3-(3′′-methyl-2′′-butenyl)benzaldehyde (2), were isolated from a gorgonian-derived Eurotium sp. fungus. Their structures were determined by… Continue reading Two benzaldehyde derivatives and their artefacts from a gorgonian-derived Eurotiumsp. fungus
Leah Pandiscia, PhD
July 28, 2017
The cardiac ankyrin repeat protein (CARP) is up-regulated in the myocardium during cardiovascular disease and in response to mechanical or… Continue reading CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex
Leah Pandiscia, PhD
July 28, 2017
By using spectroscopic methods (fluorescence and circular dichroism), the interactions of three di-fluorinated chalcones (CH23F, CH25F and CH35F) with bovine… Continue reading Evaluating the interaction between di-fluorinated chalcones and plasmatic albumin
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Triosephosphate isomerase (TIM; EC 5.3.1.1) is a key enzyme involved in glycolysis and gluconeogenesis. Glycolysis is one of the most… Continue reading Structural insights from a novel invertebrate triosephosphate isomerase from Litopenaeus vannamei
Leah Pandiscia, PhD
July 28, 2017
Mannanases are important enzymes which are widely used as a tool in agriculture and food industries. To improve the performance… Continue reading Mannanase Man23 Mutants Library Construction Basing on a Novel Cell-free Protein Expression System
Leah Pandiscia, PhD
July 28, 2017
A novel artificial cellulase was developed by conjugating a DNA aptamer to an endoglucanase catalytic domain, thereby substituting the natural… Continue reading A salt-switchable artificial cellulase regulated by a DNA aptamer
Leah Pandiscia, PhD
July 28, 2017
The cysteine-rich neurotoxins from elapid venoms are primarily responsible for human and animal envenomation; however, their low concentration in the… Continue reading Heterologous expression, protein folding and antibody recognition of a neurotoxin from the Mexican coral snakeMicrurus laticorallis
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Dysfunctional interaction of amyloid-β (Aβ) with excess metal ions is proved to be related to the etiology of Alzheimer’s disease… Continue reading Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer’s disease
Leah Pandiscia, PhD
July 28, 2017