(+)-Mahanimbine (1), a prenylated carbazole alkaloid, was isolated from the stems of Murraya koenigii. Herein we developed a divergent synthesis by… Continue reading Divergent synthesis of prenylated carbazole alkaloid (+)-S-mahanimbine led to the discovery of a notch activator
Leah Pandiscia, PhD
July 28, 2017
As an emerging nanomaterial, quantum dots (QDs) have received enormous attention for their excellent photophysical properties. However, their biotoxicity restricts… Continue reading Influence of mercaptopropionic-acid-capped CdTe quantum dots on the human chorionic gonadotropin structure and activity alterations
Leah Pandiscia, PhD
July 28, 2017
Extracellular matrix (ECM), comprised of multiple cues (chemical, physiomechanical), provides a niche for cell attachment, migration, and differentiation. Given that… Continue reading Tunable Crosslinked Cell-Derived Extracellular Matrix Guides Cell Fate
Leah Pandiscia, PhD
July 28, 2017
The interaction of anti-tuberculosis drug pyrazinamide (PYZ) with serum albumins (HSA and BSA) has been studied using spectroscopic and molecular… Continue reading Comparative binding study of anti-tuberculosis drug pyrazinamide with serum albumins
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are involved in airway hyperresponsiveness (AHR) and inflammation. However the role of nociceptin… Continue reading Nociceptin reduces the inflammatory immune microenvironment in a conventional murine model of airway hyperresponsiveness
Leah Pandiscia, PhD
July 28, 2017
A chiral Cu(II) metal–organic framework, [H2N(CH3)2]2[Cu(L)]·5.5DMF (1), was constructed using a diisophthalate ligand with an active pyridyl site, 2,6-di(3′,5′-dicarboxylphenyl)pyridine (H4L).… Continue reading A chiral metal–organic framework with polar channels: unique interweaving six-fold helices and high CO2/CH4 separation
Leah Pandiscia, PhD
July 28, 2017
Recently, highly lipophilic S-geranylated derivatives of 5-methylaminomethyl-2-thiouridine (mnm5geS2U) and 5-carboxymethylaminomethyl-2-thiouridine (cmnm5geS2U) were found at the first (wobble) anticodon position in bacterial… Continue reading S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterization
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Sortase mediated transpeptidation reactions play a significant role in covalent attachment of surface proteins to the cell wall of Gram-positive… Continue reading Active site analysis of sortase A from Staphylococcus simulansindicates function in cleavage of putative cell wall proteins
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Harmalol administration caused remarkable reduction in proliferation of HepG2 cells with GI50 of 14.2 μM, without showing much cytotoxicity in embryonic liver cell… Continue reading DNA binding and apoptotic induction ability of harmalol in HepG2: Biophysical and biochemical approaches
Leah Pandiscia, PhD
July 28, 2017
Phytochemical investigation of the ethanolic extract of Grangea maderaspatana led to isolation of gramaderins A–D, together with thirteen known compounds. All isolates… Continue reading Diterpenes from Grangea maderaspatana
Leah Pandiscia, PhD
July 28, 2017
G-quadruplex forming sequences are particularly enriched in the promoter regions of eukaryotic genes, especially of oncogenes. One of the most… Continue reading Discovery of a Family of Genomic Sequences Which Interact Specifically with the c-MYC Promoter to Regulate c-MYC Expression
Leah Pandiscia, PhD
July 28, 2017
From stromata (fruiting bodies) of three xylariaceous fungi belonging to the genusAnnulohypoxylon (A. leptascum, A. cf. truncatum and an unidentified Annulohypoxylonsp.), truncatone A (1), three… Continue reading Truncatones A–D, benzo[j]fluoranthenes fromAnnulohypoxylon species (Xylariaceae, Ascomycota)
Leah Pandiscia, PhD
July 28, 2017
The GH10 endo-xylanase from Thermoascus aurantiacus CBMAI 756 (XynA) is industrially attractive due to its considerable thermostability and high specific activity. Considering the… Continue reading Engineering increased thermostability in the GH-10 endo-1,4-β-xylanase from Thermoascus aurantiacus CBMAI 756
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Keratins as fibrous proteins, offer structural integrity to various tissues in providing the functional role of protection or load bearing.… Continue reading Transient Structures of Keratins from Hoof and Horn Influence Their Self Association and Supramolecular Assemblies
Leah Pandiscia, PhD
July 28, 2017
Two novel imidazole derived Schiff bases, (Z)-1-(1H-benzo[d]imidazol-2-yl)-N-benzylidenemethanamine (L1) and 1-(1H-benzo[d]imidazol-2-yl)-N-(4-nitrobenzylidene) methanamine, and a series of their transition metal complexes of… Continue reading A treatise on benzimidazole based Schiff base metal(II) complexes accentuating their biological efficacy: Spectroscopic evaluation of DNA interactions, DNA cleavage and antimicrobial screening
Leah Pandiscia, PhD
July 28, 2017