Leah Pandiscia, PhD
July 28, 2017
A monoaza-15-crown-5 lariat ether derived from d-glucose 1 has been applied as a chiral phase-transfer catalyst in the Michael addition of diethyl, dimethyl,… Continue reading Crown ether derived from d-glucose as an efficient phase-transfer catalyst for the enantioselective Michael addition of malonates to enones
Leah Pandiscia, PhD
July 28, 2017
Three pentacyclic triterpene dilactones were isolated from the fruiting bodies ofGanoderma colossum, a medicinal mushroom. Colossolactone H (colo H) as… Continue reading Colossolactone H, a new Ganoderma triterpenoid exhibits cytotoxicity and potentiates drug efficacy of gefitinib in lung cancer
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Four fawcettimine-type (palhicerines A–D, resp.) and two lycopodine-type (palhicerines E and F) Lycopodium alkaloids together with twenty known ones were isolated from… Continue reading Palhicerines A–F, Lycopodium alkaloids from the club moss Palhinhaea cernua
Leah Pandiscia, PhD
July 28, 2017
Nucleotide-free kinesin motor domains from several kinesin families convert reversibly to a refractory conformation that cannot rapidly rebind ADP. In… Continue reading Nucleotide-free kinesin motor domains reversibly convert to an inactive conformation with characteristics of a molten globule
Leah Pandiscia, PhD
July 28, 2017
Mutations in the human SLC26A4/Pendrin polypeptide (hPDS) cause Pendred Syndrome /DFNB4, syndromic deafness with enlargement of the vestibular aqueduct and… Continue reading Human SLC26A4/Pendrin STAS domain is a nucleotide-binding protein: Refolding and Characterization for Structural Studies
Leah Pandiscia, PhD
July 28, 2017
The research on protein-polymer conjugates by grafting from the surface of proteins has gained significant interest in the last decade.… Continue reading Grafting PNIPAAm from ß-barrel shaped transmembrane nanopores
Leah Pandiscia, PhD
July 28, 2017
The leukotriene A4 hydrolase (LTA4H) is a bifunctional enzyme, containing a peptidase and a hydrolase activity both activities having opposing functions… Continue reading Thermodynamic properties of leukotriene A4 hydrolase inhibitors
Leah Pandiscia, PhD
July 28, 2017
The present work is a brief overview of technical applications of surfactant that involves membrane interactions, and surfactant-based protocols to… Continue reading Effect of 1,4-bis(3-dodecylimidazolium-1-yl) butane bromide on channel form of gramicidin vesicles
Leah Pandiscia, PhD
July 28, 2017
The upper aerial parts and leaf tips of Myrothamnus flabellifolia Welw. (Myrothamnaceae), a resurrection plant indigenous to southern Africa, are used in… Continue reading Qualitative and quantitative phytochemical characterization of Myrothamnus flabellifolia Welw
Leah Pandiscia, PhD
July 28, 2017
Phospholipase A2 (named bitanarin) possessing capability to block nicotinic acetylcholine receptors (nAChRs) was isolated earlier (Vulfius et al., 2011) from puff adder Bitis… Continue reading Peptides from puff adder Bitis arietans venom, novel inhibitors of nicotinic acetylcholine receptors
Leah Pandiscia, PhD
April 2, 2018
Fisetin (3,3′,4′,7-tetrahydroxyflavone) has been found to be neuroprotective, induce neuronal differentiation, enhance memory, and inhibit the aggregation of the amyloid… Continue reading Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid β protein
Leah Pandiscia, PhD
July 28, 2017
Single-walled carbon nanotubes (SWNTs) have been considered as the leading candidate for nanodevice applications ranging from gene therapy and novel… Continue reading Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B–A transition in solution
Leah Pandiscia, PhD
July 28, 2017
Stromal interaction molecules (STIM) 1 and STIM2 are regulators of store-operated calcium (Ca2+) entry as well as basal cytoplasmic Ca2+ levels… Continue reading Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics
Leah Pandiscia, PhD
July 28, 2017
We have investigated the conformational transition and aggregation process of recombinant Syrian hamster prion protein (SHaPrP90–232) by Fourier transform infrared… Continue reading Formation of Critical Oligomers Is a Key Event during Conformational Transition of Recombinant Syrian Hamster Prion Protein
Leah Pandiscia, PhD
July 28, 2017
T30177 is a G-rich oligonucleotide with the sequence (GTGGTGGGTGGGTGGGT) which inhibits the HIV-1 integrase activity at nanomolar concentrations. Here we show… Continue reading HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The interaction of an essential transport protein bovine serum albumin (BSA) and albumin-gold nanoconjugates (BSA-GNPs) with amino acid l-aspartic (ASP) are… Continue reading Interaction of bovine serum albumin and albumin-gold nanoconjugates with l-aspartic acid. A spectroscopic approach
Leah Pandiscia, PhD
July 28, 2017
New l-glutamic acid based dendritic compounds: N-(2-naphthacarbonyl)-l-glutamic acid diethyl ester (NGE) and N-(2-naphthacarbonyl)-1,5-bis(l-glutamic acid diethyl ester)-l-glutamic diamide (NBGE) were designed. Although NGE could… Continue reading Ultrasound induced formation of organogel from a glutamic dendron
Leah Pandiscia, PhD
July 28, 2017