Puerarin and daidzein are the major naturally occurring isoflavones in leguminous plants. These two compounds are metabolized to equol by… Continue reading Biotransformation of C-Glucosylisoflavone Puerarin to Estrogenic (3S)-Equol in Co-culture of Two Human Intestinal Bacteria
Leah Pandiscia, PhD
July 28, 2017
Two plumbagic acid glucosides, 3′-O-β-glucopyranosyl plumbagic acid and 3′-O-β-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone… Continue reading Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica
Leah Pandiscia, PhD
July 28, 2017
Cinnamycin is a unique toxin in that its receptor, phosphatidylethanolamine (PE), resides in the inner layer of the plasma membrane.… Continue reading Cinnamycin (Ro 09-0198) Promotes Cell Binding and Toxicity by Inducing Transbilayer Lipid Movement
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The flavonoids are a large class of polyphenolic compounds which occur naturally in plants where they are widely distributed. Isovitexin… Continue reading Binding of antioxidant flavone isovitexin to human serum albumin investigated by experimental and computational assays
Leah Pandiscia, PhD
July 28, 2017
Human Respiratory Syncytial Virus is one of the major causes of acute respiratory infections in children, causing bronchiolitis and pneumonia.… Continue reading Experimental evidence and molecular modeling of the interaction between hRSV-NS1 and quercetin
Leah Pandiscia, PhD
July 28, 2017
Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii.… Continue reading Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii
Leah Pandiscia, PhD
July 28, 2017
Many bacteria, particularly pathogens, possess methionine sulfoxide reductase A (MsrA) and B (MsrB) as a fusion form (MsrAB). However, it… Continue reading Essential Role of the Linker Region in the Higher Catalytic Efficiency of a Bifunctional MsrA–MsrB Fusion Protein
Leah Pandiscia, PhD
July 28, 2017
Protein – ligand interactions play pivotal role in almost all the biological processes occurring in living organisms, and therefore such… Continue reading Probing the binding of anticancer drug topotecan with human hemoglobin: Structural and thermodynamic studies
Leah Pandiscia, PhD
July 28, 2017
The synthesis and molecular/morphological characterization of poly(L-lactic acid-co-glycolic acid) P(L-LA/GA) copolymers were investigated. The optimum reaction conditions were first determined… Continue reading Molecular and morphological characterization of poly(L-lactic acid-co-glycolic acid) P(L-LA/GA) copolymers prepared by Azeotropic distillation
Leah Pandiscia, PhD
July 28, 2017
The propensity of native state to form aggregated and fibrillar assemblies is a hallmark of amyloidosis. Our study was focused… Continue reading Analysing Cytochrome c Aggregation and Fibrillation upon Interaction with Acetonitrile: an in Vitro Study
Leah Pandiscia, PhD
July 28, 2017
The HIV gp41 ectodomain (e-gp41) is an attractive target for the development of vaccines and drugs against HIV because of… Continue reading Molecular and Physicochemical Factors Governing Solubility of the HIV gp41 Ectodomain
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Folding reaction mechanisms of globular protein domains have been extensively studied both by experiment and simulation and found to be… Continue reading Activation barrier-limited folding and conformational sampling of a dynamic protein domain
Leah Pandiscia, PhD
July 28, 2017
Many proteins expressed in Escherichia coli cells form inclusion bodies that are neither refoldable nor soluble in buffers. Very surprisingly, we recently… Continue reading Resurrecting Abandoned Proteins with Pure Water: CD and NMR Studies of Protein Fragments Solubilized in Salt-Free Water
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Two chiral coordination polymers involving amino acid backbone l-cysteic acid (H2l-cys) and N-donor ligand 4,4′-bipyridine (4,4′-bpy) [{Cd(l-cys)(4,4′-bpy)(H2O)}3.5H2O]n1, [{Zn2(l-cys)2(4,4′-bpy)2(H2O)4}·(H2O)·(4,4′-bpy)]n2 with rectangular grids have… Continue reading Structural diversity in two dimensional chiral coordination polymers involving 4,4′-bipyridine and l-cysteate as bridging ligands with Zn and Cd metal centres: Synthesis, characterization and X-ray crystallographic studies
Leah Pandiscia, PhD
July 28, 2017
Two new glycosides, 7S,7′S,8R,8′R-icariol A2-9-O-β-D-glucopyranoside (1) and 4-allyl-2-hydroxyphenyl 1-O-β-D-apiosyl-(1→6)-β-D-glucopyranoside (2), were isolated from the dried whole plants of Glechoma hederacea L. (Labiatae)… Continue reading Two New Glycosides from the Whole Plants of Glechoma hederacea L.
Leah Pandiscia, PhD
July 28, 2017
The stator in F1F0-ATP synthase resists strain generated by rotor torque. In Escherichia coli theb 2δ subunit complex comprises the stator, bound to… Continue reading F1F0-ATP Synthase BINDING OF δ SUBUNIT TO A 22-RESIDUE PEPTIDE MIMICKING THE N-TERMINAL REGION OF α SUBUNIT
Leah Pandiscia, PhD
July 28, 2017
The asymmetric oxidative coupling polymerization (AOCP) of 2,3-dihydroxynaphthalene (DHN) with a novel catalyst system, oxovanadium(IV) stearate in the presence of… Continue reading Novel vanadium catalyst system with tartaric acid salts for highly selective asymmetric oxidative coupling polymerization
Leah Pandiscia, PhD
July 28, 2017