The azobenzene-substituted diacetylene (NADA) LB films were fabricated and their chiroptical properties were investigated in detail. It was found that the NADA LB films showed… Continue reading Chiroptical switch based on azobenzene-substituted polydiacetylene LB films under thermal and photic stimuli
Leah Pandiscia, PhD
May 24, 2018
Leah Pandiscia, PhD
July 28, 2017
Lead ions in solution interact strongly with human serum albumin and modify the properties and function of albumin molecules. In… Continue reading Structural changes of human serum albumin in response to a low concentration of heavy ions
Leah Pandiscia, PhD
July 28, 2017
By using DNA or a peptide as a common probe, graphene-based biosensing has made significant progress. However, to the best of our knowledge, a graphene-based chiral sensor… Continue reading Chiral detection using reusable fluorescent amylose-functionalized graphene
Leah Pandiscia, PhD
July 28, 2017
Integrin-mediated cell adhesion to extracellular matrix proteins anchors cells and triggers signals that direct cell function. The integrin α2β1 recognizes… Continue reading Engineering integrin-specific surfaces with a triple-helical collagen-mimetic peptide
Leah Pandiscia, PhD
July 28, 2017
Three new gelsedine-type oxindole alkaloids, GS-1, GS-2, and GS-3, and one new iridoid, GSIR-1, were isolated from the stems and… Continue reading New Oxindole Alkaloids and Iridoid from Carolina jasmine (Gelsemium sempervirens AIT. f.)
Leah Pandiscia, PhD
July 28, 2017
The aggregation of β-amyloid (1–40) (Aβ) induced by human recombinant acetylcholinesterase (HuAChE) was studied by means of circular dichroism (CD)… Continue reading β-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies
Leah Pandiscia, PhD
July 28, 2017
It is widely recognized that adsorbed proteins on biomaterial surfaces tend to initiate thrombus formation, although the specific mechanisms involved… Continue reading Direct correlation between adsorption-induced changes in protein structure and platelet adhesion
Leah Pandiscia, PhD
July 28, 2017
It is well established that the prion protein (PrP) contains metal ion binding sites with specificity for copper. Changes in… Continue reading Effect of metal ions on de novo aggregation of full-length prion protein
Leah Pandiscia, PhD
July 28, 2017
Understanding a protein’s dielectric response requires both a theoretical model and a well-defined experimental system. The former has already been… Continue reading The Complex of Apomyoglobin with the Fluorescent Dye Coumarin 153
Leah Pandiscia, PhD
July 28, 2017
This paper reports the first experimental evidence on binding of the plant derived curcumin molecule to human α1-acid glycoprotein (AGP),… Continue reading Induced circular dichroism spectra reveal binding of the antiinflammatory curcumin to human α1-acid glycoprotein
Leah Pandiscia, PhD
July 28, 2017
We have successfully synthesized both enantiomers of a novel chiral ionic liquid, (R)- and (S)-[(3-chloro-2-hydroxypropyl) trimethylammonium][bis((trifluoromethyl)sulfonyl)amide] ((R)- and (S)-[CHTA]+[Tf2N]-) in… Continue reading Chiral Ionic Liquid that Functions as Both Solvent and Chiral Selector for the Determination of Enantiomeric Compositions of Pharmaceutical Products
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Bovine dermis was exposed outdoors in the Antarctic in 2013 to study the skin damage caused by short-wavelength ultraviolet light… Continue reading Exposure of bovine dermal tissue to ultraviolet light under the Antarctic ozone hole
Leah Pandiscia, PhD
July 28, 2017
Aptamer-protein interaction studies have been mainly confined to dissociation constant (Kd) determination. A combinatorial approach involving limited proteolysis mass spectroscopy,… Continue reading Multifaceted analyses of the interactions between human heart type fatty acid binding protein and its specific aptamers
Leah Pandiscia, PhD
July 28, 2017
In this paper, we show that chitosan may induce conformation changes in silk fibroin (SF) in layer-by-layer (LbL) films, which… Continue reading Silk fibroin organization induced by chitosan in layer-by-layer films: application as a matrix in a biosensor
Leah Pandiscia, PhD
July 28, 2017
Five new metabolites including four β-resorcylic macrolides 1–4 and one octahydronaphthalene derivative 5 were isolated from a seagrass-derived fungusFusarium sp. PSU-ES123 together with seven known… Continue reading β-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp. PSU-ES123
Leah Pandiscia, PhD
July 28, 2017
A variety of receptors for hyaluronate (HA), a natural linear polysaccharide, were found in the body, which have been exploited… Continue reading Targeted Systemic Mesenchymal Stem Cell Delivery Using Hyaluronate – Wheat Germ Agglutinin Conjugate
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in embryogenesis and cancer. Sterols activate the membrane protein Smoothened… Continue reading Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling
Leah Pandiscia, PhD
July 28, 2017