Leah Pandiscia, PhD
July 28, 2017
Collagen mimetic peptide (CMP) with a specific amino acid sequence, –(Pro–Hyp–Gly)x–, forms a triple helix conformation that resembles the native… Continue reading Collagen mimetic peptide-conjugated photopolymerizable PEG hydrogel
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Atropisomerism is one of the basic concepts in stereochemistry. Chiral crystals of stereochemically labile atropisomers that originated from Mirror Symmetry… Continue reading Concentration effects in solid-state CD spectra of chiral atropisomeric compounds
Leah Pandiscia, PhD
July 28, 2017
Proline oligopeptides composed of 13, 6 and 4 Pro residues were synthesized by solid-phase procedure. The circular dichroism spectra showed… Continue reading On the Stability of Polyproline-I and II Structures of Proline Oligopeptides
Leah Pandiscia, PhD
July 28, 2017
An experimental and computational study on the conformational preference of 1,n′-disubstituted ferrocenoyl amino acids and dipeptides is presented. Only l-amino acids… Continue reading 1,n′-Disubstituted ferrocenoyl amino acids and dipeptides: Conformational analysis by CD spectroscopy, X-ray crystallography, and DFT calculations
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
It is well established that the rate of formation of fibrils by amyloidogenic proteins is enhanced by the addition of… Continue reading Observation of sequence specificity in the seeding of protein amyloid fibrils
Leah Pandiscia, PhD
July 28, 2017
Recently cytochrome c has been mentioned as an important mediator in the events of cellular oxidative stress and apoptosis. To investigate the… Continue reading Effect of Heme Iron Valence State on the Conformation of Cytochrome c and Its Association with Membrane Interfaces
Leah Pandiscia, PhD
July 28, 2017
A new flavan-3-ol glycoside, (−)-epicatechin-5-O-β-d-glucosyl-3-benzoate (1), and two known compounds, (−)-epicatechin and (−)-epiafzelechin, were isolated from an EtOAc extract ofCelastrus… Continue reading Antioxidant Benzoylated Flavan-3-ol Glycoside from Celastrusorbiculatus
Leah Pandiscia, PhD
July 28, 2017
Fourier transform infrared (FTIR) and CD spectroscopy have been used to investigate the structural effects of G-tract length and flanking… Continue reading An FTIR and CD study of the structural effects of G-tract length and sequence context on DNA conformation in solution
Leah Pandiscia, PhD
July 28, 2017
Tritrpticin, a Trp-rich cationic antimicrobial peptide with a unique amino acid sequence (VRRFPWWWPFLRR), is found in porcine cathelicidin cDNA. Tritrpticin… Continue reading Conformation-dependent antibiotic activity of tritrpticin, a cathelicidin-derived antimicrobial peptide
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Nine new melodinus-type alkaloids, melohemsines A-I (1-9), together with eight known ones were isolated from Melodinus hemselyanus. The structures of… Continue reading Melohemsines A-I, melodinus-type alkaloids from Melodinus hemsleyanus
Leah Pandiscia, PhD
July 28, 2017
Nanostructures including hydrogels based on peptides containing non protein amino acids are being considered as platform for drug delivery because… Continue reading A novel highly stable and injectable hydrogel based on a conformationally restricted ultrashort peptide
Leah Pandiscia, PhD
July 28, 2017
Bisphenol S (BPS) is present in multitudinous consumer products and detected in both the food and water. It also has… Continue reading Bisphenol S Interacts with Catalase and Induces Oxidative Stress in Mouse Liver and Renal Cells
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Antibody drug conjugates (ADC) are important next-generation biopharmaceuticals and thus require stringent structure characterization as is the case for monoclonal… Continue reading Biophysical characterization of a model antibody drug conjugate
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
DGCR8 is the RNA binding partner of the nuclease Drosha. Their complex (the “Microprocessor”) is essential for processing of long,… Continue reading Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex
Leah Pandiscia, PhD
July 28, 2017