Two small molecules showed intriguing properties of analytical multipurpose probes, whereby one chromophore gives different signal for many different DNA/RNA… Continue reading Small molecule probes finely differentiate between various ds- and ss-DNA and RNA by fluorescence, CD and NMR response
Leah Pandiscia, PhD
July 28, 2017
The structure-specific nuclease human flap endonuclease-1 (hFEN1) plays a key role in DNA replication and repair and may be of… Continue reading Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
Leah Pandiscia, PhD
July 28, 2017
The ability to precisely and remotely modulate reversible binding interactions between biomolecules and abiotic surfaces is appealing for many applications.… Continue reading Optical Modulation of Azobenzene-Modified Peptide for Gold Surface Binding
Leah Pandiscia, PhD
July 28, 2017
The direct electrochemistry and electrocatalysis of cytochrome c (Cyt c) based on dandelion-like bismuth sulfide (d-Bi2S3) nanoflowers have been developed. The morphologies and… Continue reading Direct electrochemistry and electrocatalysis of cytochrome c based on dandelion-like Bi2S3nanoflowers
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
DehI is a homodimeric haloacid dehalogenase from Pseudomonas putida that contains the most complex 61 Stevedore’s protein knot within its… Continue reading Folding analysis of the most complex Stevedore’s protein knot
Leah Pandiscia, PhD
July 28, 2017
A 1:1 mixture of pseudoenantiomeric aminomethylenehelicene oligomers, (P)-tetramer and (M)-pentamer, in fluorobenzene show a self-catalytic phenomenon in the formation of… Continue reading Spatially Heterogeneous Nature of Self-Catalytic Reaction in Hetero-Double Helix Formation of Helicene Oligomers
Leah Pandiscia, PhD
July 28, 2017
Two new hexahydrobenzo[c] phenanthridine alkaloids, ambiguanine H (1) and ambiguanine I (2) together with six known hexahydrobenzo[c] phenanthridine alkaloids (3–8),… Continue reading Protective effect of hexahydrobenzo[c]phenanthridine alkaloids isolated from Corydalis ambigua var. amurensis on myocardial ischemia-hypoxia cells
Leah Pandiscia, PhD
July 28, 2017
Proteins show remarkable versatility as multifunctional materials for therapeutic applications. They can be easily modified with the toolkit of bioorganic… Continue reading Methods of protein surface PEGylation under structure preservation for the emulsion-based formation of stable nanoparticles
Leah Pandiscia, PhD
July 28, 2017
Improvement in the in vitro and in vivo stability of biotherapeutic proteins has been approached viaa number of strategies, including protein PEGylation or formulation with… Continue reading Impact of PEGylation and non-ionic surfactants on the physical stability of the therapeutic protein filgrastim (G-CSF)
Leah Pandiscia, PhD
July 28, 2017
A supramolecular porphyrin nanotube displaying J-aggregation feature was constructed by out-ofplane coordinated bismuth-porphyrin. Significantly, compared to traditional J-aggregated porphyrin suffering… Continue reading Out-of-Plane Coordinated Porphyrin Nanotubes with Enhanced Singlet Oxygen Generation Efficiency
Leah Pandiscia, PhD
July 28, 2017
Bisphenol A is widely used in the manufacture of food packaging and beverage containers and can invade our food and… Continue reading Deciphering the toxicity of bisphenol a to Candida rugosa lipase through spectrophotometric methods
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Membrane-active peptides (MAPs), which interact directly with the lipid bilayer of a cell and include toxins and host defense peptides,… Continue reading The Interaction of Melittin with Dimyristoyl Phosphatidylcholine-Dimyristoyl Phosphatidylserine Lipid Bilayer Membranes
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
KRAS promoter can form G-quadruplex structure and regulate gene transcription. The drugs which can bind with G-quadruplex of KRAS promoter may be potential… Continue reading Spectroscopic investigation of the interaction between G-quadruplex of KRAS promoter sequence and three isoquinoline alkaloids
Leah Pandiscia, PhD
July 28, 2017
Snake venom Kunitz-type serine protease inhibitors (KSPIs) exhibit various biological functions including anticoagulant activity. This study elucidates the occurrence and… Continue reading Structural and functional characterization of complex formation between two Kunitz-type serine protease inhibitors from Russell’s Viper venom
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The ultrasound treatment on whey protein before enzymatic hydrolysis using vegetable proteases was studied. Ultrasound density, temperature, and pretreatment time… Continue reading Impact of ultrasound pretreatment on whey protein hydrolysis by vegetable proteases
Leah Pandiscia, PhD
July 28, 2017