Relaxin-3 or insulin-like peptide 7 (INSL7) is the most recently discovered relaxin/insulin-like family peptide. Mature relaxin-3 consists of an A… Continue reading Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity
Leah Pandiscia, PhD
July 28, 2017
The absolute configuration of phytotoxins inuloxins B and C, produced by Inula viscosa, and with potential herbicidal activity for the management… Continue reading Absolute configurations of phytotoxic inuloxins B and C based on experimental and computational analysis of chiroptical properties
Leah Pandiscia, PhD
July 28, 2017
The Esx-1 cluster encodes a special secretion system that is important for granuloma formation and virulence when Mycobacterium tuberculosis infects the host.… Continue reading Expression, purification and characterization of Esx-1 secretion-associated protein EspL from Mycobacterium tuberculosis
Leah Pandiscia, PhD
July 28, 2017
An antimicrobial triple-helical peptide, R3, was previously obtained from a collagen-like combinatorial peptide library. In the present research, based on structure–activity… Continue reading Structure–Activity Relationships and Action Mechanisms of Collagen-like Antimicrobial Peptides
Leah Pandiscia, PhD
July 28, 2017
Single-domain antibodies derived from the unique New Antigen Receptor found in sharks have numerous potential applications, ranging from diagnostic reagents… Continue reading Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein
Leah Pandiscia, PhD
July 28, 2017
Antimicrobial peptides (AMPs), due to their unique structure/function relationship, have great potential to be developed into novel diagnostic and therapeutic… Continue reading Orientation Determination of a Hybrid Peptide Immobilized on CVD-Based Reactive Polymer Surfaces
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Two chiral complexes (1-SDS, and 1-SDBS) were prepared via the ionic self-assembly of a chiral perylene diimide tecton with oppositely… Continue reading Chiral Perylene Materials by Ionic Self-Assembly
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Octreotide and pasireotide are two cyclic somatostatin analogues with an important clinical use in the treatment and diagnosis of neuroendocrine… Continue reading From bulk to plasmonic nanoparticle surface: behavior of two potent therapeutic peptides, octreotide and pasireotide
Leah Pandiscia, PhD
July 28, 2017
Amyloid fibrils are a large class of self-assembled protein aggregates that are formed from unstructured peptides and unfolded proteins. The… Continue reading Multimodal Spectroscopic Study of Amyloid Fibril Polymorphism
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Zinc complexes of 3-hydroxymethyl-131-oxo-chlorins possessing various π-conjugatable substituents at the 8-position were prepared by chemical modification of naturally occurring chlorophyll-a.… Continue reading Visible and Near-Infrared Spectra of Chlorosomal Zinc Chlorin Self-Aggregates Dependent on Their Peripheral Substituents at the 8-Position
Leah Pandiscia, PhD
July 28, 2017
Calpain-5 is a calcium-activated protease expressed in the retina. Mutations in calpain-5 cause autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, OMIM#193235).… Continue reading Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains
Leah Pandiscia, PhD
July 28, 2017
Structural comparisons of the cold adapted subtilase VPR and its thermophilic homologue, aqualysin I (AQUI) indicated the presence of additional… Continue reading A single mutation Gln142Lys doubles the catalytic activity of VPR, a cold adapted subtilisin-like serine proteinase
Leah Pandiscia, PhD
July 28, 2017
The transesterification reaction of series pyrimidine acyclonucleosides was carried out with lipase (EC 3.1.1.3) Amano PS from Burkholderia cepacia (BCL) as biocatalyst.… Continue reading Enantio- and diastereoselective acylation of prochiral hydroxyl group of pyrimidine acyclonucleosides
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
A newly designed cyclic bis-naphthyridine carbamate dimer CMBL4 with a limited conformational flexibility was synthesized and characterized. Absorption spectra revealed that two… Continue reading Cyclic mismatch binding ligand CMBL4 binds to the 5′-T-3′/5′-GG-3′ site by inducing the flipping out of thymine base
Leah Pandiscia, PhD
July 28, 2017
α-synuclein (α-syn) is the main component of Lewy bodies, which are neuropathological hallmarks of patients with Parkinson’s disease. As it… Continue reading A small-angle X-ray scattering study of alpha-synuclein from human red blood cells
Leah Pandiscia, PhD
July 28, 2017