2021 / ChemBioChem
Abnormally expanded CAG/CTG repeat DNA sequences lead to a variety of neurological diseases, such as Huntington’s disease. Here, we synthesized… Continue reading Strong and Specific Recognition of CAG/CTG Repeat DNA (5’-dWGCWGCW-3’) by a Cyclic Pyrrole-Imidazole Polyamide
2021 / Nature Communications
Inactivation of the phytohormone auxin plays important roles in plant development, and several enzymes have been implicated in auxin inactivation.… Continue reading The main oxidative inactivation pathway of the plant hormone auxin
2021 / Nature Communications
During injured tissue regeneration, the extracellular matrix plays a key role in controlling and coordinating various cellular events by binding… Continue reading Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration
2021 / Nature Communications
Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced… Continue reading Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation
2021 / Nature Communications
The acidic tumor microenvironment in melanoma drives immune evasion by up-regulating cyclic adenosine monophosphate (cAMP) in tumor-infiltrating monocytes. Here we… Continue reading Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
2021 / Nature Communications
The acidic tumor microenvironment in melanoma drives immune evasion by up-regulating cyclic adenosine monophosphate (cAMP) in tumor-infiltrating monocytes. Here we… Continue reading Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
2021 / Nature Communications
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is… Continue reading Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
2021 / Nature Communications
Introns of human transfer RNA precursors (pre-tRNAs) are excised by the tRNA splicing endonuclease TSEN in complex with the RNA… Continue reading Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia
2021 / Nature Communications
Canine parvovirus type II (CPV-2) infection induces canine parvoviral enteritis (CPE), which in turn promotes sepsis and systemic inflammatory response… Continue reading Increased survival in puppies affected by Canine Parvovirus type II using an immunomodulator as a therapeutic aid
2021 / Processes 2021
Liquefaction of waste lignocellulosic biomass is a viable technology for replacing fossil fuels and meeting sustainable development goals. In this… Continue reading Preparation and Evaluation of Epoxy Resin Prepared from the Liquefied Product of Cotton Stalk
2021 / Nature Communications
Mutations in the type 1 ryanodine receptor (RyR1), a Ca2+ release channel in skeletal muscle, hyperactivate the channel to cause… Continue reading A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
2021 / Enzyme and microbial technology
The ene reductases (ERs) from the old yellow enzymes (OYEs) family have the ability to reduce activated alkenes to generate… Continue reading Identification of four ene reductases and their preliminary exploration in the asymmetric synthesis of (R)-dihydrocarvone and (R)-profen derivatives
2021 / Scientific reports
Thermophilic biohydrogen production by dark fermentation from a mixture (1:1) of C5 (arabinose) and C6 (glucose) sugars, present in lignocellulosic… Continue reading Zeolite addition to improve biohydrogen production from dark fermentation of C5/C6-sugars and Sargassum sp. Biomass
2021 / Scientific reports
Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses… Continue reading Pseudoboehmite as a drug delivery system for acyclovir
2021 / Nature Communications
Biological membranes play pivotal roles in the cellular activities. Transmembrane proteins are the central molecules that conduct membrane-mediated biochemical functions… Continue reading A synthetic ion channel with anisotropic ligand response
2021 / Environmental Science and Pollution Research
Sampling, separation, detection, and characterization of microplastics (MPs) dispersed in natural water bodies and ecosystems is a challenging and critical… Continue reading New methodologies for the detection, identification, and quantification of microplastics and their environmental degradation by-products
2021 / Scientific Report
Attachment of polysaccharide carriers is increasingly being used to achieve precision delivery and improved effectiveness of protein and peptide drugs.… Continue reading A physicochemical assessment of the thermal stability of dextrin–colistin conjugates
2021 / Scientific Report
Cell-penetrating peptides have important therapeutic applications in drug delivery, but the variety of known cell-penetrating peptides is still limited. With… Continue reading Using molecular dynamics simulations to prioritize and understand AI-generated cell penetrating peptides
2021 / Scientific Report
Temperature-responsive chromatography using thermoresponsive polymers is innovative and can control analyte retention via column temperature. Analyte elution behavior in this… Continue reading Effect of pore diameter on the elution behavior of analytes from thermoresponsive polymer grafted beads packed columns
2021 / Scientific Report
In patients with chronic kidney disease, skeletal muscle dysfunction is associated with mortality. Uremic sarcopenia is caused by ageing, malnutrition,… Continue reading β2-adrenergic receptor agonist counteracts skeletal muscle atrophy and oxidative stress in uremic mice
