Imaging Matrix Metalloproteinase Activity Implicated in Breast Cancer Progression

By Gregg B Fields, Maciej J. Stawikowski

July 28, 2017

  • Year

  • Technique

  • Industry

Title

Imaging Matrix Metalloproteinase Activity Implicated in Breast Cancer Progression

Author

Gregg B Fields, Maciej J. Stawikowski

Year

2016

Journal

Methods in Molecular Biology

Abstract

Proteolysis has been cited as an important contributor to cancer initiation and progression. One can take advantage of tumor-associated proteases to selectively deliver imaging agents. Protease-activated imaging systems have been developed using substrates designed for hydrolysis by members of the matrix metalloproteinase (MMP) family. We presently describe approaches by which one can optically image matrix metalloproteinase activity implicated in breast cancer progression, with consideration of selective versus broad protease probes.

Full Article

http://link.springer.com/protocol/10.1007/978-1-4939-3444-7_25

Instrument

J-810

Keywords

Circular dichroism, Medicinal