Title
Palcernuine, the first [5/6/6/6]-cernuane-type alkaloid fromPalhinhaea cernua f. sikkimensis
Author
Yu Tang, Juan Xiong, Yike Zou, Bastien Nay, Li-Jun Wang, Jin-Feng Hu
Year
2016
Journal
Chinese Chemical Letters
Abstract
One novel (named palcernuine, 1) and five known cernuane-type (2–6) alkaloids were isolated from the whole plant of Palhinhaea cernua f. sikkimensis. The structure of 1, possessing an unprecedented [5/6/6/6]-tetracyclic ring system containing two nitrogen atoms, was established on the basis of spectroscopic methods, and its absolute configuration was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway to 1 is proposed.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Medicinal