Title
Anti-inflammatory amide alkaloids from the stems of Clausena emarginata
Author
Hong-Min Xia, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Li Li, Dan Zhang, Xiu-Qi Bao, Dong-Ming Zhang
Year
2014
Journal
Journal of Asian Natural Products Research
Abstract
Two new amide alkaloids, clauemaramide A (1) and clauemaramide B (2), and three known analogs were isolated from the stems of Clausena emarginata. Their structures were determined on the basis of spectroscopic analyses. The absolute configurations of 1and 2 were confirmed by CD spectroscopy. Compound 3 showed moderate inhibitory effects on LPS-induced NO production (IC50 value = 4.9 μM).
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products