Penicillars A–E from the marine animal endogenic fungusPenicillium sp. SCS-KFD08

By Fan Dong Kong, Li Man Zhou, Qing Yun Ma, Sheng Zhuo Huang, Pei Wang, Hao-Fu Dai, You-Xing Zhao

July 28, 2017

  • Year

  • Technique

  • Industry

Title

Penicillars A–E from the marine animal endogenic fungusPenicillium sp. SCS-KFD08

Author

Fan Dong Kong, Li Man Zhou, Qing Yun Ma, Sheng Zhuo Huang, Pei Wang, Hao-Fu Dai, You-Xing Zhao

Year

2016

Journal

Phytochemistry Letters

Abstract

Five new compounds named penicillars A–E were isolated from the fermentation broth ofPenicillium sp. SCS-KFD08 associated with the marine animal Sipunculus nudus from the Haikou bay of China. Their planar structures and absolute configurations were unambiguously elucidated by spectroscopic data, Mo2(OAc)4 induced CD spectrum analysis along with quantum ECD calculation. Among them, compounds 2 and 3, at a concentration of 50 μg/mL, showed weak inhibitory activity against AChE with inhibition rates of 19.5% and 21.3%, respectively.

Full Article

http://www.sciencedirect.com/science/article/pii/S1874390016301112

Instrument

J-715

Keywords

Circular dichroism, Absolute configuration, Agricultural and environmetal