Title
2,15-Dihydroxy-hexahelicene (HELIXOL): synthesis and use as an enantioselective fluorescent sensor
Author
Manfred T Reetz, Stefan Sostmann
Year
2001
Journal
Tetrahedron
Abstract
The helical diol 2,15-dihydroxy-hexahelicene (HELIXOL) is an excellent fluorescence sensor for chiral amines and amino alcohols. The fluorescence of HELIXOL can be efficiently as well as enantioselectively quenched by the enantiomers of several chiral amines and amino alcohols. Its high fluorescence intensity and its ability to enantiodiscriminate effectively makes it potentially useful for high-throughput screening of ee.
Instrument
J-715
Keywords
Circular dichroism, Stereochemistry,