Title
On the synthesis of cyclodextrin–peptide conjugates by the Huisgen reaction
Author
Rémy Lartia, Christopher K. Jankowski, Sébastien Arseneau
Year
2016
Journal
Journal of Peptide Science
Abstract
A,D-substituted cyclodextrin (CDX) substituted on their primary rim side are ideal scaffolds for the macromolecular assembly and formation of templated structures. Their substitution can be achieved through various reactions. However, the use of the well-known Huisgen reaction in this context is under-reported. We present here results of the synthesis of model conjugates formed between CDX and representative peptides by click chemistry. Notably, bis-conjugation of peptides onto a unique scaffold promotes α-helix formation.
Instrument
J-810
Keywords
Circular dichroism, Secondary structure, Ligand binding, Biochemistry