Petroquinones: trimeric and dimeric xestoquinone derivatives isolated from the marine sponge Petrosia alfiani

By Natsuki Tanokashira, Sanako Kukita, Hikaru Kato, Tatsuo Nehira, Esther D. Angkouw, Remy E.P. Mangindaan, Nicole J. de Voogd, Sachiko Tsukamoto

July 28, 2017

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Title

Petroquinones: trimeric and dimeric xestoquinone derivatives isolated from the marine sponge Petrosia alfiani

Author

Natsuki Tanokashira, Sanako Kukita, Hikaru Kato, Tatsuo Nehira, Esther D. Angkouw, Remy E.P. Mangindaan, Nicole J. de Voogd, Sachiko Tsukamoto

Year

2016

Journal

Tetrahedron

Abstract

We isolated 16 new xestoquinone derivatives, including two trimers, six dimers, and four monomers with containing thiomorpholine 1,1-dioxide and pyrrolidine-2,4-diol moieties, from the marine sponge Petrosia alfiani and determined their structures including the absolute configurations using computational methods. They exhibited potent inhibitory activities against USP7 with IC50 values in the range of 0.13–2.0 μM.

Full Article

http://www.sciencedirect.com/science/article/pii/S0040402016306809

Instrument

J-820

Keywords

Circular dichroism, Absolute configuration, Natural products, Pharmaceutical