Title
Adeninealkylresorcinol, the First Alkylresorcinol Tethered with Nucleobase from Lasiodiplodia sp.
Author
Yu-Meng Gao, Tian-Yu Sun, Min Ma, Guo-Dong Chen, Zheng-Qun Zhou, Chuan-Xi Wang, Dan Hu, Li-Guo Chen, Xin-Sheng Yao, Hao Gao
Year
2016
Journal
Fitoterapia
Abstract
Adeninealkylresorcinol (1), an unusual alkylresorcinol with adenine-alkylresorcinol conjoined skeleton, was isolated from an endophytic fungus Lasiodiplodia sp. obtained from a traditional Chinese medicine Houttuynia cordata Thunb., together with three new biogenetically related compounds (2–4). Their structures were elucidated by comprehensive spectroscopic analysis, and the absolute configuration of 4 was determined by the modified Mosher's method and quantum chemical calculation. Among them, adeninealkylresorcinol (1) is the first alkylresorcinol tethered with nucleobase. In addition, the antioxidant, cytotoxic, and antimicrobial activities of 1–3 were evaluated.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal