Title
Cephalotanins A–D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons fromCephalotaxus sinensis
Author
Jin-Biao Xu, Yao-Yue Fan, Dr. Li-She Gan, Yu-Bo Zhou, Jia Li, Jian-Min Yue
Year
2016
Journal
Chemistry A European Journal
Abstract
Four polycyclic norditerpenoids, cephalotanins A–D (1–4) representing three unprecedented carbon skeletons with highly rigid ring systems, were isolated from Cephalotaxus sinensis and structurally characterized by a combination of various methods. Compounds 1 and 2 are new skeletal norditerpenoid trilactones, while 3 and 4 are two norditerpenoids featuring different new carbon skeletons. Biosynthetic pathways for 1–4 were proposed by involving diverse and very fascinating chemical events with the coexisting cephalotane troponoids as the precursors. Compound 1exhibited good NF-κB inhibition with an IC50 value of 4.12±0.61 μΜ.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Medicinal, Pharmaceutical