Title
Truncatones A–D, benzo[j]fluoranthenes fromAnnulohypoxylon species (Xylariaceae, Ascomycota)
Author
Enge Sudarman, Eric Kuhnert, Kevin D. Hyde, Esteban Benjamin Sir, Frank Surup, Marc Stadler
Year
2016
Journal
Tetrahedron
Abstract
From stromata (fruiting bodies) of three xylariaceous fungi belonging to the genusAnnulohypoxylon (A. leptascum, A. cf. truncatum and an unidentified Annulohypoxylonsp.), truncatone A (1), three unprecedented derivatives named truncatones B–D (2–4) besides the known 4,5,4′,5′-tetrahydroxy-1,1′-binaphthyl (BNT, 5), hypoxylonol C (6) and hypoxylonol F (7) were isolated. Planar structures of the new benzo[j]fluoranthene derivatives 2–4 were determined on the basis of NMR and HRESIMS data. While the relative configuration of 4 was demonstrated by ROESY NMR data and 1H,1H coupling constants, absolute configurations of 1, 2, 4 were determined by CD spectroscopy. Compounds 1, 3 and 4 exhibited cytotoxicity against the mouse fibroblast cell line L929.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Pharmaceutical