Title
Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum
Author
Wan Gao, Jia-Wen Hu, Fang Xu, Can-Jing Wei, Meng-Jiao Shi, Jun Zhao, Jia-Jia Wang, Bo Zhen, Teng-Fei Ji, Jian-Guo Xing, Zheng-Yi Gu, Fang Xu
Year
2016
Journal
Fitoterapia
Abstract
Four new polyisoprenylated benzoylphloroglucinol derivatives, hyperscabrones J-M (1–4), were isolated from the air-dried aerial parts of Hypericum scabrum. Their structures were elucidated by spectroscopic methods and were subsequently confirmed by comparing with data of known compounds. The absolute configuration of the bicyclo[3.3.1]nonane-2,4,9-trione core was defined by the experimental and calculated electronic circular dichroism (ECD) spectra. The evaluation of their hepatoprotective activities against paracetamol-induced HepG2 cell damage showed that compounds 2and 4 exhibited significant hepatoprotection at 10 μM.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Medicinal